Seroatlas · Human Serome Atlas

PYGB

Glycogen phosphorylase, brain form

Also known as: PYGB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P11216
Gene: PYGB
Ensembl: ENSG00000100994
Chromosome: 20
Canonical length: 843 aa
Protein class: Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

843 residues, UniProt reviewed canonical sequence.

>P11216|PYGB
     1  MAKPLTDSEK RKQISVRGLA GLGDVAEVRK SFNRHLHFTL VKDRNVATPR DYFFALAHTV
    61  RDHLVGRWIR TQQHYYERDP KRIYYLSLEF YMGRTLQNTM VNLGLQNACD EAIYQLGLDL
   121  EELEEIEEDA GLGNGGLGRL AACFLDSMAT LGLAAYGYGI RYEFGIFNQK IVNGWQVEEA
   181  DDWLRYGNPW EKARPEYMLP VHFYGRVEHT PDGVKWLDTQ VVLAMPYDTP VPGYKNNTVN
   241  TMRLWSAKAP NDFKLQDFNV GDYIEAVLDR NLAENISRVL YPNDNFFEGK ELRLKQEYFV
   301  VAATLQDIIR RFKSSKFGCR DPVRTCFETF PDKVAIQLND THPALSIPEL MRILVDVEKV
   361  DWDKAWEITK KTCAYTNHTV LPEALERWPV SMFEKLLPRH LEIIYAINQR HLDHVAALFP
   421  GDVDRLRRMS VIEEGDCKRI NMAHLCVIGS HAVNGVARIH SEIVKQSVFK DFYELEPEKF
   481  QNKTNGITPR RWLLLCNPGL ADTIVEKIGE EFLTDLSQLK KLLPLVSDEV FIRDVAKVKQ
   541  ENKLKFSAFL EKEYKVKINP SSMFDVHVKR IHEYKRQLLN CLHVVTLYNR IKRDPAKAFV
   601  PRTVMIGGKA APGYHMAKLI IKLVTSIGDV VNHDPVVGDR LKVIFLENYR VSLAEKVIPA
   661  ADLSQQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM AEEAGAENLF IFGLRVEDVE
   721  ALDRKGYNAR EYYDHLPELK QAVDQISSGF FSPKEPDCFK DIVNMLMHHD RFKVFADYEA
   781  YMQCQAQVDQ LYRNPKEWTK KVIRNIACSG KFSSDRTITE YAREIWGVEP SDLQIPPPNI
   841  PRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PYGB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.2
Highest tissue expression: 165 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 165 nTPM
heart muscle: 154 nTPM
colon: 136 nTPM
blood vessel: 126 nTPM
cerebellum: 120 nTPM
salivary gland: 118 nTPM

Single-cell type

salivary duct cells: 283 nCPM
somatotrophs: 213 nCPM
salivary basal cells: 188 nCPM
smooth muscle cells: 175 nCPM
salivary ionocytes: 173 nCPM
lacrimal acinar cells: 170 nCPM

Immune cell

non-classical monocyte: 24 nTPM
total PBMC: 23 nTPM
intermediate monocyte: 19 nTPM
myeloid DC: 15 nTPM
classical monocyte: 14 nTPM
naive CD8 T-cell: 13 nTPM

Brain region

spinal cord: 146 nTPM
medulla oblongata: 146 nTPM
white matter: 141 nTPM
cerebellum: 141 nTPM
midbrain: 139 nTPM
pons: 135 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

glycogen catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PYGB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PYGB as an antibody target. Whether an autoantibody or antibody against PYGB could matter depends on whether native PYGB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PYGB is annotated as secreted, so native PYGB circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PYGB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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