Seroatlas · Human Serome Atlas

UTP18

U3 small nucleolar RNA-associated protein 18 homolog

Also known as: CGI-48, UTP18_HUMAN, WDR50

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5J1
Gene: UTP18
Ensembl: ENSG00000011260
Chromosome: 17
Canonical length: 556 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in nuclear membrane; nucleolus; and nucleoplasm. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>Q9Y5J1|UTP18
     1  MPPERRRRMK LDRRTGAKPK RKPGMRPDWK AGAGPGGPPQ KPAPSSQRKP PARPSAAAAA
    61  IAVAAAEEER RLRQRNRLRL EEDKPAVERC LEELVFGDVE NDEDALLRRL RGPRVQEHED
   121  SGDSEVENEA KGNFPPQKKP VWVDEEDEDE EMVDMMNNRF RKDMMKNASE SKLSKDNLKK
   181  RLKEEFQHAM GGVPAWAETT KRKTSSDDES EEDEDDLLQR TGNFISTSTS LPRGILKMKN
   241  CQHANAERPT VARISSVQFH PGAQIVMVAG LDNAVSLFQV DGKTNPKIQS IYLERFPIFK
   301  ACFSANGEEV LATSTHSKVL YVYDMLAGKL IPVHQVRGLK EKIVRSFEVS PDGSFLLING
   361  IAGYLHLLAM KTKELIGSMK INGRVAASTF SSDSKKVYAS SGDGEVYVWD VNSRKCLNRF
   421  VDEGSLYGLS IATSRNGQYV ACGSNCGVVN IYNQDSCLQE TNPKPIKAIM NLVTGVTSLT
   481  FNPTTEILAI ASEKMKEAVR LVHLPSCTVF SNFPVIKNKN ISHVHTMDFS PRSGYFALGN
   541  EKGKALMYRL HHYSDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

testis: 55 nTPM
bone marrow: 38 nTPM
tonsil: 32 nTPM
skin: 31 nTPM
lymph node: 31 nTPM
thymus: 26 nTPM

Single-cell type

late spermatids: 269 nCPM
early spermatids: 208 nCPM
late primary spermatocytes: 202 nCPM
oocytes: 184 nCPM
early primary spermatocytes: 125 nCPM
differentiating spermatogonia: 113 nCPM

Immune cell

T-reg: 57 nTPM
total PBMC: 56 nTPM
myeloid DC: 56 nTPM
memory B-cell: 54 nTPM
naive CD4 T-cell: 54 nTPM
naive B-cell: 53 nTPM

Brain region

cerebellum: 34 nTPM
white matter: 26 nTPM
choroid plexus: 25 nTPM
hypothalamus: 24 nTPM
cerebral cortex: 24 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0
gnomAD missense Z: -0.21
DepMap mean gene effect: -1.09
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
U3 small nucleolar RNA-associated protein 18

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UTP18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PWP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP18 as an antibody target. Whether an autoantibody or antibody against UTP18 could matter depends on whether native UTP18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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