Seroatlas · Human Serome Atlas

PROSER1

Proline and serine-rich protein 1

Also known as: bA50D16.2, C13orf23, FLJ12661, PRSR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XN7
Gene: PROSER1
Ensembl: ENSG00000120685
Chromosome: 13
Canonical length: 944 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a conserved protein containing proline and serine rich regions. These regions may be important in protein-protein interactions. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

944 residues, UniProt reviewed canonical sequence.

>Q86XN7|PROSER1
     1  MDKKSFEMVL DEIRKAVLTE YKLKAIEYVH GYFSSEQVVD LLRYFSWAEP QLKAMKALQH
    61  KMVAVQPTEV VNILNCFTFS KDKLVALELL ASNIIDAQNS RPIEDLFRVN MSEKKRCKRI
   121  LEQAFKGGCK APHAMISSCG TIPGNPYPKG RPSRINGIFP GTPLKKDGEE CTNEGKGIAA
   181  RILGPSKPPP STYNPHKPVP YPIPPCRPHA TIAPSAYNNA GLVPLANVIA PPPPPYTPNP
   241  VGTENEDLSN PSKPIQNQTF STPASQLFSP HGSNPSTPAA TPVPTASPVK AINHPSASAA
   301  ATVSGMNLLN TVLPVFPGQV SSAVHTPQPS IPNPTVIRTP SLPTAPVTSI HSTTTTPVPS
   361  IFSGLVSLPG PSATPTAATP TPGPTPRSTL GSSEAFASTS APFTSLPFST SSSAASTSNP
   421  NSASLSSVFA GLPLPLPPTS QGLSNPTPVI AGGSTPSVAG PLGVNSPLLS ALKGFLTSND
   481  TNLINSSALS SAVTSGLASL SSLTLQNSDS SASAPNKCYA PSAIPTPQRT STPGLALFPG
   541  LPSPVANSTS TPLTLPVQSP LATAASASTS VPVSCGSSAS LLRGPHPGTS DLHISSTPAA
   601  TTLPVMIKTE PTSPTPSAFK GPSHSGNPSH GTLGLSGTLG RAYTSTSVPI SLSACLNPAL
   661  SGLSSLSTPL NGSNPLSSIS LPPHGSSTPI APVFTALPSF TSLTNNFPLT GNPSLNPSVS
   721  LPGSLIATSS TAATSTSLPH PSSTAAVLSG LSASAPVSAA PFPLNLSTAV PSLFSVTQGP
   781  LSSSNPSYPG FSVSNTPSVT PALPSFPGLQ APSTVAAVTP LPVAATAPSP APVLPGFASA
   841  FSSNFNSALV AQAGLSSGLQ AAGSSVFPGL LSLPGIPGFP QNPSQSSLQE LQHNAAAQSA
   901  LLQQVHSASA LESYPAQPDG FPSYPSAPGT PFSLQPSLSQ SGWQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROSER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 24 nTPM
placenta: 20 nTPM
skin: 15 nTPM
cerebellum: 15 nTPM
pancreas: 15 nTPM
tonsil: 14 nTPM

Single-cell type

cardiomyocytes: 48 nCPM
syncytiotrophoblasts: 35 nCPM
oocytes: 32 nCPM
thymocytes: 32 nCPM
neutrophil progenitors: 30 nCPM
monocyte progenitors: 30 nCPM

Immune cell

basophil: 4.5 nTPM
NK-cell: 4.2 nTPM
MAIT T-cell: 3.1 nTPM
memory CD8 T-cell: 3 nTPM
gdT-cell: 2.8 nTPM
memory CD4 T-cell: 2.8 nTPM

Brain region

cerebellum: 17 nTPM
medulla oblongata: 17 nTPM
white matter: 17 nTPM
cerebral cortex: 15 nTPM
pons: 15 nTPM
midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.71
gnomAD missense Z: 0.14
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Domain of unknown function DUF4476
Proline and serine-rich protein 1
Domain of unknown function (DUF4476)

KeywordsUniProt

Acetylation

InteractionsUniProt · HPA

Protein binding partners of PROSER1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROSER1 as an antibody target. Whether an autoantibody or antibody against PROSER1 could matter depends on whether native PROSER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROSER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PROSER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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