Seroatlas · Human Serome Atlas

PRDM15

PR domain zinc finger protein 15

Also known as: C21orf83, PRD15_HUMAN, ZNF298

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57071
Gene
PRDM15
Ensembl
ENSG00000141956
Chromosome
21
Canonical length
1141 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1141 residues, UniProt reviewed canonical sequence.

>P57071|PRDM15
     1  MAEDGSEEIM FIWCEDCSQY HDSECPELGP VVMVKDSFVL SRARSSLPPN LEIRRLEDGA
    61  EGVFAITQLV KRTQFGPFES RRVAKWEKES AFPLKVFQKD GHPVCFDTSN EDDCNWMMLV
   121  RPAAEAEHQN LTAYQHGSDV YFTTSRDIPP GTELRVWYAA FYAKKMDKPM LKQAGSGVHA
   181  AGTPENSAPV ESEPSQWACK VCSATFLELQ LLNEHLLGHL EQAKSLPPGS QSEAAAPEKE
   241  QDTPRGEPPA VPESENVATK EQKKKPRRGR KPKVSKAEQP LVIVEDKEPT EQVAEIITEV
   301  PPDEPVSATP DERIMELVLG KLATTTTDTS SVPKFTHHQN NTITLKRSLI LSSRHGIRRK
   361  LIKQLGEHKR VYQCNICSKI FQNSSNLSRH VRSHGDKLFK CEECAKLFSR KESLKQHVSY
   421  KHSRNEVDGE YRYRCGTCEK TFRIESALEF HNCRTDDKTF QCEMCFRFFS TNSNLSKHKK
   481  KHGDKKFACE VCSKMFYRKD VMLDHQRRHL EGVRRVKRED LEAGGENLVR YKKEPSGCPV
   541  CGKVFSCRSN MNKHLLTHGD KKYTCEICGR KFFRVDVLRD HIHVHFKDIA LMDDHQREEF
   601  IGKIGISSEE NDDNSDESAD SEPHKYSCKR CQLTFGRGKE YLKHIMEVHK EKGYGCSICN
   661  RRFALKATYH AHMVIHRENL PDPNVQKYIH PCEICGRIFN SIGNLERHKL IHTGVKSHAC
   721  EQCGKSFARK DMLKEHMRVH DNVREYLCAE CGKGMKTKHA LRHHMKLHKG IKEYECKECH
   781  RRFAQKVNML KHCKRHTGIK DFMCELCGKT FSERNTMETH KLIHTVGKQW TCSVCDKKYV
   841  TEYMLQKHVQ LTHDKVEAQS CQLCGTKVST RASMSRHMRR KHPEVLAVRI DDLDHLPETT
   901  TIDASSIGIV QPELTLEQED LAEGKHGKAA KRSHKRKQKP EEEAGAPVPE DATFSEYSEK
   961  ETEFTGSVGD ETNSAVQSIQ QVVVTLGDPN VTTPSSSVGL TNITVTPITT AAATQFTNLQ
  1021  PVAVGHLTTP ERQLQLDNSI LTVTFDTVSG SAMLHNRQND VQIHPQPEAS NPQSVAHFIN
  1081  LTTLVNSITP LGSQLSDQHP LTWRAVPQTD VLPPSQPQAP PQQAAQPQVQ AEQQQQQMYS
  1141  Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRDM15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
7.7 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 7.7 nTPM
  • tonsil: 6.9 nTPM
  • appendix: 4.2 nTPM
  • skeletal muscle: 4.2 nTPM
  • spleen: 4 nTPM
  • skin: 3.7 nTPM

Single-cell type

  • plasma cells: 33 nCPM
  • myonuclei: 26 nCPM
  • adipocytes: 19 nCPM
  • lactotrophs: 19 nCPM
  • megakaryocyte-erythroid progenitors: 19 nCPM
  • adrenal cortex cells: 17 nCPM

Immune cell

  • intermediate monocyte: 0.8 nTPM
  • memory B-cell: 0.6 nTPM
  • eosinophil: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • myeloid DC: 0.4 nTPM
  • total PBMC: 0.4 nTPM

Brain region

  • amygdala: 5.4 nTPM
  • cerebral cortex: 5.4 nTPM
  • basal ganglia: 5.3 nTPM
  • hippocampal formation: 5.1 nTPM
  • white matter: 4.9 nTPM
  • midbrain: 4.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRDM15.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 284 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0
gnomAD missense Z
2.42
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRDM15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRDM15 as an antibody target. Whether an autoantibody or antibody against PRDM15 could matter depends on whether native PRDM15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRDM15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRDM15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRDM15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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