DNA mismatch repair, conserved site

Definition

Mismatch repair contributes to the overall fidelity of DNA replication PMID:3304141. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The sequence of some proteins involved in mismatch repair in different organisms have been found to be evolutionarily related. These proteins include: Escherichia coli and Salmonella typhimurium mutL protein PMID:2676972. MutL is required for dam-dependent methyl-directed DNA repair. Streptococcus pneumoniae hexB protein PMID:2676973. The Hex system is nick directed. Yeast proteins PMS1 and MLH1 PMID:8264608. Human protein MLH1 PMID:8145827 which is involved in a form of familial hereditary nonpolyposis colon cancer (HNPCC). This entry represents a perfectly conserved heptapeptide which is located in the N-terminal section of these proteins.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• MLH1
• MLH3
• PMS1
• PMS2
• PMS2P1
• SLC25A42