Seroatlas · Human Serome Atlas

PLIN5

Perilipin-5

Also known as: LSDA5, LSDP5, MLDP, OXPAT, PLIN5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q00G26
Gene
PLIN5
Ensembl
ENSG00000214456
Chromosome
19
Canonical length
463 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Lipid droplets
Quaternary structure
Homooligomer

OverviewNCBI Gene

Predicted to enable identical protein binding activity and lipase binding activity. Predicted to be involved in several processes, including negative regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of triglyceride storage; and regulation of lipid metabolic process. Located in intracellular membrane-bounded organelle and lipid droplet. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>Q00G26|PLIN5
     1  MSEEEAAQIP RSSVWEQDQQ NVVQRVVALP LVRATCTAVC DVYSAAKDRH PLLGSACRLA
    61  ENCVCGLTTR ALDHAQPLLE HLQPQLATMN SLACRGLDKL EEKLPFLQQP SETVVTSAKD
   121  VVASSVTGVV DLARRGRRWS VELKRSVSHA VDVVLEKSEE LVDHFLPMTE EELAALAAEA
   181  EGPEVGSVED QRRQQGYFVR LGSLSARIRH LAYEHSVGKL RQSKHRAQDT LAQLQETLEL
   241  IDHMQCGVTP TAPACPGKVH ELWGEWGQRP PESRRRSQAE LETLVLSRSL TQELQGTVEA
   301  LESSVRGLPA GAQEKVAEVR RSVDALQTAF ADARCFRDVP AAALAEGRGR VAHAHACVDE
   361  LLELVVQAVP LPWLVGPFAP ILVERPEPLP DLADLVDEVI GGPDPRWAHL DWPAQQRAWE
   421  AEHRDGSGNG DGDRMGVAGD ICEQEPETPS CPVKHTLMPE LDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLIN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
200 nTPM

Expression across tissuesHPA

Tissue

  • liver: 200 nTPM
  • skeletal muscle: 142 nTPM
  • pancreas: 108 nTPM
  • ovary: 88 nTPM
  • heart muscle: 59 nTPM
  • salivary gland: 59 nTPM

Single-cell type

  • lacrimal acinar cells: 178 nCPM
  • myonuclei: 177 nCPM
  • pancreatic acinar cells: 157 nCPM
  • neutrophils: 156 nCPM
  • salivary acinar cells: 155 nCPM
  • adipocytes: 150 nCPM

Immune cell

  • neutrophil: 14 nTPM
  • basophil: 1.8 nTPM
  • eosinophil: 0.8 nTPM
  • NK-cell: 0.5 nTPM
  • classical monocyte: 0.4 nTPM
  • naive B-cell: 0.4 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • basal ganglia: 24 nTPM
  • amygdala: 23 nTPM
  • thalamus: 20 nTPM
  • midbrain: 20 nTPM
  • cerebral cortex: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.66
gnomAD pLI
0
gnomAD missense Z
-0.52
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLIN5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLIN5 as an antibody target. Whether an autoantibody or antibody against PLIN5 could matter depends on whether native PLIN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLIN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLIN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLIN5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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