Seroatlas · Human Serome Atlas

LIPE

Hormone-sensitive lipase

Also known as: HSL, LIPS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q05469
Gene: LIPE
Ensembl: ENSG00000079435
Chromosome: 19
Canonical length: 1076 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1076 residues, UniProt reviewed canonical sequence.

>Q05469|LIPE
     1  MEPGSKSVSR SDWQPEPHQR PITPLEPGPE KTPIAQPESK TLQGSNTQQK PASNQRPLTQ
    61  QETPAQHDAE SQKEPRAQQK SASQEEFLAP QKPAPQQSPY IQRVLLTQQE AASQQGPGLG
   121  KESITQQEPA LRQRHVAQPG PGPGEPPPAQ QEAESTPAAQ AKPGAKREPS APTESTSQET
   181  PEQSDKQTTP VQGAKSKQGS LTELGFLTKL QELSIQRSAL EWKALSEWVT DSESESDVGS
   241  SSDTDSPATM GGMVAQGVKL GFKGKSGYKV MSGYSGTSPH EKTSARNHRH YQDTASRLIH
   301  NMDLRTMTQS LVTLAEDNIA FFSSQGPGET AQRLSGVFAG VREQALGLEP ALGRLLGVAH
   361  LFDLDPETPA NGYRSLVHTA RCCLAHLLHK SRYVASNRRS IFFRTSHNLA ELEAYLAALT
   421  QLRALVYYAQ RLLVTNRPGV LFFEGDEGLT ADFLREYVTL HKGCFYGRCL GFQFTPAIRP
   481  FLQTISIGLV SFGEHYKRNE TGLSVAASSL FTSGRFAIDP ELRGAEFERI TQNLDVHFWK
   541  AFWNITEMEV LSSLANMASA TVRVSRLLSL PPEAFEMPLT ADPTLTVTIS PPLAHTGPGP
   601  VLVRLISYDL REGQDSEELS SLIKSNGQRS LELWPRPQQA PRSRSLIVHF HGGGFVAQTS
   661  RSHEPYLKSW AQELGAPIIS IDYSLAPEAP FPRALEECFF AYCWAIKHCA LLGSTGERIC
   721  LAGDSAGGNL CFTVALRAAA YGVRVPDGIM AAYPATMLQP AASPSRLLSL MDPLLPLSVL
   781  SKCVSAYAGA KTEDHSNSDQ KALGMMGLVR RDTALLLRDF RLGASSWLNS FLELSGRKSQ
   841  KMSEPIAEPM RRSVSEAALA QPQGPLGTDS LKNLTLRDLS LRGNSETSSD TPEMSLSAET
   901  LSPSTPSDVN FLLPPEDAGE EAEAKNELSP MDRGLGVRAA FPEGFHPRRS SQGATQMPLY
   961  SSPIVKNPFM SPLLAPDSML KSLPPVHIVA CALDPMLDDS VMLARRLRNL GQPVTLRVVE
  1021  DLPHGFLTLA ALCRETRQAA ELCVERIRLV LTPPAGAGPS GETGAAGVDG GCGGRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIPE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 784 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 784 nTPM
breast: 524 nTPM
spinal cord: 137 nTPM
testis: 66 nTPM
midbrain: 66 nTPM
blood vessel: 65 nTPM

Single-cell type

adipocytes: 452 nCPM
late spermatids: 403 nCPM
early spermatids: 179 nCPM
retinal pigment epithelial cells: 64 nCPM
late primary spermatocytes: 60 nCPM
oligodendrocytes: 60 nCPM

Immune cell

basophil: 11 nTPM
classical monocyte: 8.6 nTPM
intermediate monocyte: 4.7 nTPM
naive B-cell: 4.5 nTPM
eosinophil: 3.8 nTPM
memory CD8 T-cell: 3.7 nTPM

Brain region

white matter: 248 nTPM
medulla oblongata: 225 nTPM
pons: 182 nTPM
cerebellum: 176 nTPM
midbrain: 168 nTPM
basal ganglia: 160 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LIPE.

Disease | AllUniProt

Conditions LIPE is implicated in, by any mechanism.

Lipodystrophy, familial partial, 6 (FPLD6) MIM:615980

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 280 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

LIPE-related familial partial lipodystrophy
Lipodystrophy - childhood onset

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Alpha/beta hydrolase fold-3
Alpha/Beta hydrolase fold
Lipase, GDXG, putative serine active site
alpha/beta hydrolase fold
Lipase, GDXG, putative histidine active site
Hormone-sensitive lipase, N-terminal
Hormone-sensitive lipase (HSL) N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIPE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIPE as an antibody target. Whether an autoantibody or antibody against LIPE could matter depends on whether native LIPE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIPE is annotated at the cell surface, where native LIPE is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LIPE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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