Seroatlas · Human Serome Atlas

PLIN3

Perilipin-3

Also known as: M6PRBP1, PLIN3_HUMAN, PP17, TIP47

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60664
Gene: PLIN3
Ensembl: ENSG00000105355
Chromosome: 19
Canonical length: 434 aa
Protein class: FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Lipid droplets
Quaternary structure: Homodimer

OverviewNCBI Gene

Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>O60664|PLIN3
     1  MSADGAEADG STQVTVEEPV QQPSVVDRVA SMPLISSTCD MVSAAYASTK ESYPHIKTVC
    61  DAAEKGVRTL TAAAVSGAQP ILSKLEPQIA SASEYAHRGL DKLEENLPIL QQPTEKVLAD
   121  TKELVSSKVS GAQEMVSSAK DTVATQLSEA VDATRGAVQS GVDKTKSVVT GGVQSVMGSR
   181  LGQMVLSGVD TVLGKSEEWA DNHLPLTDAE LARIATSLDG FDVASVQQQR QEQSYFVRLG
   241  SLSERLRQHA YEHSLGKLRA TKQRAQEALL QLSQVLSLME TVKQGVDQKL VEGQEKLHQM
   301  WLSWNQKQLQ GPEKEPPKPE QVESRALTMF RDIAQQLQAT CTSLGSSIQG LPTNVKDQVQ
   361  QARRQVEDLQ ATFSSIHSFQ DLSSSILAQS RERVASAREA LDHMVEYVAQ NTPVTWLVGP
   421  FAPGITEKAP EEKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

esophagus: 124 nTPM
skeletal muscle: 112 nTPM
skin: 86 nTPM
small intestine: 70 nTPM
adrenal gland: 68 nTPM
bone marrow: 67 nTPM

Single-cell type

esophageal apical cells: 1,077 nCPM
breast lactating cells: 715 nCPM
enterocytes: 343 nCPM
esophageal suprabasal cells: 324 nCPM
suprabasal keratinocytes: 274 nCPM
syncytiotrophoblasts: 255 nCPM

Immune cell

neutrophil: 175 nTPM
classical monocyte: 142 nTPM
basophil: 129 nTPM
myeloid DC: 109 nTPM
intermediate monocyte: 100 nTPM
total PBMC: 86 nTPM

Brain region

white matter: 116 nTPM
medulla oblongata: 92 nTPM
pons: 77 nTPM
cerebellum: 76 nTPM
thalamus: 69 nTPM
basal ganglia: 65 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLIN3.

Disease | ImmuneIEDB

Conditions an epitope on PLIN3 was assayed in.

Lyme disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cadherin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLIN3 as an antibody target. Whether an autoantibody or antibody against PLIN3 could matter depends on whether native PLIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLIN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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