Seroatlas · Human Serome Atlas

PLIN2

Perilipin-2

Also known as: ADFP, ADRP, PLIN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99541
Gene: PLIN2
Ensembl: ENSG00000147872
Chromosome: 9
Canonical length: 437 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Lipid droplets

OverviewNCBI Gene

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q99541|PLIN2
     1  MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA ENGVKTITSV
    61  AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP STQIVANAKG AVTGAKDAVT
   121  TTVTGAKDSV ASTITGVMDK TKGAVTGSVE KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL
   181  TKSELLVEQY LPLTEEELEK EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK
   241  EAKQKSQQTI SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES
   301  HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA GDIYSVFRNA
   361  ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQLT ESQNAQDQGA
   421  EMDKSSQETQ RSEHKTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 846 nTPM

Expression across tissuesHPA

Tissue

liver: 846 nTPM
adipose tissue: 617 nTPM
breast: 470 nTPM
skeletal muscle: 429 nTPM
heart muscle: 222 nTPM
duodenum: 175 nTPM

Single-cell type

syncytiotrophoblasts: 2,943 nCPM
breast lactating cells: 2,322 nCPM
extravillous trophoblasts: 1,144 nCPM
monocytes: 901 nCPM
mast cells: 855 nCPM
hepatocytes: 722 nCPM

Immune cell

basophil: 778 nTPM
eosinophil: 583 nTPM
non-classical monocyte: 170 nTPM
intermediate monocyte: 150 nTPM
classical monocyte: 111 nTPM
total PBMC: 106 nTPM

Brain region

thalamus: 100 nTPM
cerebral cortex: 82 nTPM
white matter: 26 nTPM
pons: 23 nTPM
medulla oblongata: 21 nTPM
basal ganglia: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLIN2.

Disease | ImmuneIEDB

Conditions an epitope on PLIN2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.96
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IRGC

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLIN2 as an antibody target. Whether an autoantibody or antibody against PLIN2 could matter depends on whether native PLIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLIN2 is annotated at the cell surface, where native PLIN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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