Seroatlas · Human Serome Atlas

MEAF6

Chromatin modification-related protein MEAF6

Also known as: C1orf149, CENP-28, Eaf6, EAF6_HUMAN, FLJ11730, NY-SAR-91

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAF1
Gene: MEAF6
Ensembl: ENSG00000163875
Chromosome: 1
Canonical length: 191 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q9HAF1|MEAF6
     1  MAMHNKAAPP QIPDTRRELA ELVKRKQELA ETLANLERQI YAFEGSYLED TQMYGNIIRG
    61  WDRYLTNQKN SNSKNDRRNR KFKEAERLFS KSSVTSAAAV SALAGVQDQL IEKREPGSGT
   121  ESDTSPDFHN QENEPSQEDP EDLDGSVQGV KPQKAASSTS SGSHHSSHKK RKNKNRHRID
   181  LKLNKKPRAD Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEAF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

prostate: 54 nTPM
parathyroid gland: 49 nTPM
thymus: 47 nTPM
seminal vesicle: 42 nTPM
hypothalamus: 41 nTPM
ovary: 38 nTPM

Single-cell type

oocytes: 327 nCPM
prostatic glandular cells: 245 nCPM
esophageal apical cells: 235 nCPM
epididymal efferent duct ciliated cells: 207 nCPM
differentiating spermatogonia: 199 nCPM
suprabasal keratinocytes: 183 nCPM

Immune cell

eosinophil: 124 nTPM
total PBMC: 115 nTPM
T-reg: 110 nTPM
basophil: 109 nTPM
memory B-cell: 103 nTPM
naive B-cell: 103 nTPM

Brain region

hypothalamus: 61 nTPM
basal ganglia: 43 nTPM
cerebral cortex: 43 nTPM
midbrain: 43 nTPM
pons: 42 nTPM
white matter: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.13
gnomAD missense Z: 2.23
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Chromatin modification-related protein Eaf6
Histone acetyltransferase subunit NuA4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEAF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEAF6 as an antibody target. Whether an autoantibody or antibody against MEAF6 could matter depends on whether native MEAF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEAF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEAF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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