PIP4K2B

Protein identityUniProt · HPA

UniProt accession

P78356

Gene

PIP4K2B

Ensembl

ENSG00000276293

Chromosome

17

Canonical length

416 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>P78356|PIP4K2B
     1  MSSNCTSTTA VAVAPLSASK TKTKKKHFVC QKVKLFRASE PILSVLMWGV NHTINELSNV
    61  PVPVMLMPDD FKAYSKIKVD NHLFNKENLP SRFKFKEYCP MVFRNLRERF GIDDQDYQNS
   121  VTRSAPINSD SQGRCGTRFL TTYDRRFVIK TVSSEDVAEM HNILKKYHQF IVECHGNTLL
   181  PQFLGMYRLT VDGVETYMVV TRNVFSHRLT VHRKYDLKGS TVAREASDKE KAKDLPTFKD
   241  NDFLNEGQKL HVGEESKKNF LEKLKRDVEF LAQLKIMDYS LLVGIHDVDR AEQEEMEVEE
   301  RAEDEECEND GVGGNLLCSY GTPPDSPGNL LSFPRFFGPG EFDPSVDVYA MKSHESSPKK
   361  EVYFMAIIDI LTPYDTKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFNEF MSNILT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIP4K2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

93 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIP4K2B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 47 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Autosomal recessive severe congenital neutropenia due to CSF3R deficiency
• Hereditary neutrophilia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.16

gnomAD pLI

1

gnomAD missense Z

3.05

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
• autophagosome-lysosome fusion
• cell surface receptor signaling pathway
• negative regulation of insulin receptor signaling pathway
• phosphatidylinositol phosphate biosynthetic process
• positive regulation of autophagosome assembly
• regulation of autophagy

Molecular functions

• 1-phosphatidylinositol-4-phosphate 5-kinase activity
• 1-phosphatidylinositol-5-phosphate 4-kinase activity
• ATP binding
• GTP binding
• protein homodimerization activity

Cellular components

• autophagosome
• cytosol
• endoplasmic reticulum membrane
• nucleoplasm
• nucleus
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Phosphatidylinositol-4-phosphate 4/5-kinase, core
• Phosphatidylinositol-4/5-phosphate 5/4-kinase
• Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
• Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
• Phosphatidylinositol-4-phosphate 5-Kinase

KeywordsUniProt

• Acetylation
• ATP-binding
• Cell membrane
• Cytoplasm
• Endoplasmic reticulum
• GTP-binding
• Kinase
• Lipid metabolism
• Membrane
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of PIP4K2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PIP4K2A