PIK3AP1

Protein identityUniProt · HPA

UniProt accession

Q6ZUJ8

Gene

PIK3AP1

Ensembl

ENSG00000155629

Chromosome

10

Canonical length

805 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

Quaternary structure

Homooligomer

OverviewNCBI Gene

Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and signaling receptor binding activity. Predicted to be involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of inflammatory response; and regulation of innate immune response. Predicted to be located in membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

805 residues, UniProt reviewed canonical sequence.

>Q6ZUJ8|PIK3AP1
     1  MAASGVPRGC DILIVYSPDA EEWCQYLQTL FLSSRQVRSQ KILTHRLGPE ASFSAEDLSL
    61  FLSTRCVVVL LSAELVQHFH KPALLPLLQR AFHPPHRVVR LLCGVRDSEE FLDFFPDWAH
   121  WQELTCDDEP ETYVAAVKKA ISEDSGCDSV TDTEPEDEKV VSYSKQQNLP TVTSPGNLMV
   181  VQPDRIRCGA ETTVYVIVRC KLDDRVATEA EFSPEDSPSV RMEAKVENEY TISVKAPNLS
   241  SGNVSLKIYS GDLVVCETVI SYYTDMEEIG NLLSNAANPV EFMCQAFKIV PYNTETLDKL
   301  LTESLKNNIP ASGLHLFGIN QLEEEDMMTN QRDEELPTLL HFAAKYGLKN LTALLLTCPG
   361  ALQAYSVANK HGHYPNTIAE KHGFRDLRQF IDEYVETVDM LKSHIKEELM HGEEADAVYE
   421  SMAHLSTDLL MKCSLNPGCD EDLYESMAAF VPAATEDLYV EMLQASTSNP IPGDGFSRAT
   481  KDSMIRKFLE GNSMGMTNLE RDQCHLGQEE DVYHTVDDDE AFSVDLASRP PVPVPRPETT
   541  APGAHQLPDN EPYIFKVFAE KSQERPGNFY VSSESIRKGP PVRPWRDRPQ SSIYDPFAGM
   601  KTPGQRQLIT LQEQVKLGIV NVDEAVLHFK EWQLNQKKRS ESFRFQQENL KRLRDSITRR
   661  QREKQKSGKQ TDLEITVPIR HSQHLPAKVE FGVYESGPRK SVIPPRTELR RGDWKTDSTS
   721  STASSTSNRS STRSLLSVSS GMEGDNEDNE VPEVTRSRSP GPPQVDGTPT MSLERPPRVP
   781  PRAASQRPPT RETFHPPPPV PPRGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIK3AP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

78 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.12

gnomAD pLI

1

gnomAD missense Z

2.26

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• regulation of inflammatory response
• toll-like receptor 2 signaling pathway
• toll-like receptor 4 signaling pathway
• toll-like receptor 7 signaling pathway
• toll-like receptor 9 signaling pathway

Molecular functions

• identical protein binding
• phosphatidylinositol 3-kinase regulatory subunit binding
• signaling receptor binding

Cellular components

• cytosol
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Toll/interleukin-1 receptor homology (TIR) domain
• DBB domain
• Toll/interleukin-1 receptor homology (TIR) domain superfamily
• PIK3AP1, Toll/interleukin-1 receptor domain
• B-cell PI3K Activation and Signaling Adapters
• Dof, BCAP, and BANK (DBB) motif,
• Toll/interleukin-1 receptor domain

KeywordsUniProt

• Cell membrane
• Coiled coil
• Cytoplasm
• Membrane
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of PIK3AP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GRB2
• NCK1
• NCK2