Seroatlas · Human Serome Atlas

PHF3

PHD finger protein 3

Also known as: PHF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92576
Gene: PHF3
Ensembl: ENSG00000118482
Chromosome: 6
Canonical length: 2039 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of a PHD finger-containing gene family. This gene may function as a transcription factor and may be involved in glioblastomas development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

2039 residues, UniProt reviewed canonical sequence.

>Q92576|PHF3
     1  MDIVDTFNHL IPTEHLDDAL FLGSNLENEV CEDFSASQNV LEDSLKNMLS DKDPMLGSAS
    61  NQFCLPVLDS NDPNFQMPCS TVVGLDDIMD EGVVKESGND TIDEEELILP NRNLRDKVEE
   121  NSVRSPRKSP RLMAQEQVRS LRQSTIAKRS NAAPLSNTKK ASGKTVSTAK AGVKQPERSQ
   181  VKEEVCMSLK PEYHKENRRC SRNSGQIEVV PEVSVSSSHS SVSSCLEMKD EDGLDSKHKC
   241  NNPGEIDVPS HELNCSLLSE TCVTIGEKKN EALMECKAKP VGSPLFKFSD KEEHEQNDSI
   301  SGKTGETVVE EMIATRKVEQ DSKETVKLSH EDDHILEDAG SSDISSDAAC TNPNKTENSL
   361  VGLPSCVDEV TECNLELKDT MGIADKTENT LERNKIEPLG YCEDAESNRQ LESTEFNKSN
   421  LEVVDTSTFG PESNILENAI CDVPDQNSKQ LNAIESTKIE SHETANLQDD RNSQSSSVSY
   481  LESKSVKSKH TKPVIHSKQN MTTDAPKKIV AAKYEVIHSK TKVNVKSVKR NTDVPESQQN
   541  FHRPVKVRKK QIDKEPKIQS CNSGVKSVKN QAHSVLKKTL QDQTLVQIFK PLTHSLSDKS
   601  HAHPGCLKEP HHPAQTGHVS HSSQKQCHKP QQQAPAMKTN SHVKEELEHP GVEHFKEEDK
   661  LKLKKPEKNL QPRQRRSSKS FSLDEPPLFI PDNIATIRRE GSDHSSSFES KYMWTPSKQC
   721  GFCKKPHGNR FMVGCGRCDD WFHGDCVGLS LSQAQQMGEE DKEYVCVKCC AEEDKKTEIL
   781  DPDTLENQAT VEFHSGDKTM ECEKLGLSKH TTNDRTKYID DTVKHKVKIL KRESGEGRNS
   841  SDCRDNEIKK WQLAPLRKMG QPVLPRRSSE EKSEKIPKES TTVTCTGEKA SKPGTHEKQE
   901  MKKKKVEKGV LNVHPAASAS KPSADQIRQS VRHSLKDILM KRLTDSNLKV PEEKAAKVAT
   961  KIEKELFSFF RDTDAKYKNK YRSLMFNLKD PKNNILFKKV LKGEVTPDHL IRMSPEELAS
  1021  KELAAWRRRE NRHTIEMIEK EQREVERRPI TKITHKGEIE IESDAPMKEQ EAAMEIQEPA
  1081  ANKSLEKPEG SEKQKEEVDS MSKDTTSQHR QHLFDLNCKI CIGRMAPPVD DLSPKKVKVV
  1141  VGVARKHSDN EAESIADALS STSNILASEF FEEEKQESPK STFSPAPRPE MPGTVEVEST
  1201  FLARLNFIWK GFINMPSVAK FVTKAYPVSG SPEYLTEDLP DSIQVGGRIS PQTVWDYVEK
  1261  IKASGTKEIC VVRFTPVTEE DQISYTLLFA YFSSRKRYGV AANNMKQVKD MYLIPLGATD
  1321  KIPHPLVPFD GPGLELHRPN LLLGLIIRQK LKRQHSACAS TSHIAETPES APPIALPPDK
  1381  KSKIEVSTEE APEEENDFFN SFTTVLHKQR NKPQQNLQED LPTAVEPLME VTKQEPPKPL
  1441  RFLPGVLIGW ENQPTTLELA NKPLPVDDIL QSLLGTTGQV YDQAQSVMEQ NTVKEIPFLN
  1501  EQTNSKIEKT DNVEVTDGEN KEIKVKVDNI SESTDKSAEI ETSVVGSSSI SAGSLTSLSL
  1561  RGKPPDVSTE AFLTNLSIQS KQEETVESKE KTLKRQLQED QENNLQDNQT SNSSPCRSNV
  1621  GKGNIDGNVS CSENLVANTA RSPQFINLKR DPRQAAGRSQ PVTTSESKDG DSCRNGEKHM
  1681  LPGLSHNKEH LTEQINVEEK LCSAEKNSCV QQSDNLKVAQ NSPSVENIQT SQAEQAKPLQ
  1741  EDILMQNIET VHPFRRGSAV ATSHFEVGNT CPSEFPSKSI TFTSRSTSPR TSTNFSPMRP
  1801  QQPNLQHLKS SPPGFPFPGP PNFPPQSMFG FPPHLPPPLL PPPGFGFAQN PMVPWPPVVH
  1861  LPGQPQRMMG PLSQASRYIG PQNFYQVKDI RRPERRHSDP WGRQDQQQLD RPFNRGKGDR
  1921  QRFYSDSHHL KRERHEKEWE QESERHRRRD RSQDKDRDRK SREEGHKDKE RARLSHGDRG
  1981  TDGKASRDSR NVDKKPDKPK SEDYEKDKER EKSKHREGEK DRDRYHKDRD HTDRTKSKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 37 nTPM
thymus: 29 nTPM
liver: 26 nTPM
retina: 26 nTPM
ovary: 25 nTPM
thyroid gland: 25 nTPM

Single-cell type

neutrophils: 360 nCPM
thymocytes: 297 nCPM
corticotrophs: 281 nCPM
adipocytes: 280 nCPM
neutrophil progenitors: 273 nCPM
hematopoietic stem cells: 236 nCPM

Immune cell

basophil: 16 nTPM
neutrophil: 14 nTPM
non-classical monocyte: 12 nTPM
naive CD4 T-cell: 10 nTPM
naive B-cell: 8.9 nTPM
intermediate monocyte: 8 nTPM

Brain region

cerebellum: 95 nTPM
white matter: 88 nTPM
medulla oblongata: 69 nTPM
basal ganglia: 66 nTPM
pons: 61 nTPM
hypothalamus: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 0.76
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SUPT5H

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHF3 as an antibody target. Whether an autoantibody or antibody against PHF3 could matter depends on whether native PHF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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