Seroatlas · Human Serome Atlas

PDILT

Protein disulfide-isomerase-like protein of the testis

Also known as: PDIA7, PDILT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N807
Gene: PDILT
Ensembl: ENSG00000169340
Chromosome: 16
Canonical length: 584 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has has an N-terminal ER-signal sequence, two thioredoxin (TRX) domains with non-classical Ser-Lys-Gln-Ser and Ser-Lys-Lys-Cys motifs, respectively, two TRX-like domains, and a C-terminal ER-retention sequence. The protein lacks oxidoreductase activity in vitro and probably functions as a chaperone. This gene's expression appears to be limited to the testis. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>Q8N807|PDILT
     1  MDLLWMPLLL VAACVSAVHS SPEVNAGVSS IHITKPVHIL EERSLLVLTP AGLTQMLNQT
    61  RFLMVLFHNP SSKQSRNLAE ELGKAVEIMG KGKNGIGFGK VDITIEKELQ QEFGITKAPE
   121  LKLFFEGNRS EPISCKGVVE SAALVVWLRR QISQKAFLFN SSEQVAEFVI SRPLVIVGFF
   181  QDLEEEVAEL FYDVIKDFPE LTFGVITIGN VIGRFHVTLD SVLVFKKGKI VNRQKLINDS
   241  TNKQELNRVI KQHLTDFVIE YNTENKDLIS ELHIMSHMLL FVSKSSESYG IIIQHYKLAS
   301  KEFQNKILFI LVDADEPRNG RVFKYFRVTE VDIPSVQILN LSSDARYKMP SDDITYESLK
   361  KFGRSFLSKN ATKHQSSEEI PKYWDQGLVK QLVGKNFNVV VFDKEKDVFV MFYAPWSKKC
   421  KMLFPLLEEL GRKYQNHSTI IIAKIDVTAN DIQLMYLDRY PFFRLFPSGS QQAVLYKGEH
   481  TLKGFSDFLE SHIKTKIEDE DELLSVEQNE VIEEEVLAEE KEVPMMRKGL PEQQSPELEN
   541  MTKYVSKLEE PAGKKKTSEE VVVVVAKPKG PPVQKKKPKV KEEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDILT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 117 nTPM

Expression across tissuesHPA

Tissue

stomach: 117 nTPM
testis: 18 nTPM
duodenum: 0.4 nTPM
small intestine: 0.4 nTPM
prostate: 0.2 nTPM
bone marrow: 0.1 nTPM

Single-cell type

early spermatids: 224 nCPM
late primary spermatocytes: 87 nCPM
gastric chief cells: 70 nCPM
late spermatids: 27 nCPM
mucous neck cells: 23 nCPM
parietal cells: 23 nCPM

Immune cell

plasmacytoid DC: 2.8 nTPM
basophil: 0.8 nTPM
NK-cell: 0.7 nTPM
memory B-cell: 0.5 nTPM
neutrophil: 0.5 nTPM
naive B-cell: 0.3 nTPM

Brain region

white matter: 1.3 nTPM
cerebral cortex: 1.1 nTPM
medulla oblongata: 1.1 nTPM
pons: 1.1 nTPM
hypothalamus: 0.9 nTPM
basal ganglia: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDILT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDILT as an antibody target. Whether an autoantibody or antibody against PDILT could matter depends on whether native PDILT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDILT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDILT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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