Seroatlas · Human Serome Atlas

ERO1A

ERO1-like protein alpha

Also known as: ERO1-alpha, ERO1A_HUMAN, Ero1alpha, ERO1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HE7
Gene
ERO1A
Ensembl
ENSG00000197930
Chromosome
14
Canonical length
468 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables oxidoreductase activity. Involved in cell redox homeostasis and chaperone cofactor-dependent protein refolding. Located in Golgi lumen; endoplasmic reticulum; and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q96HE7|ERO1A
     1  MGRGWGFLFG LLGAVWLLSS GHGEEQPPET AAQRCFCQVS GYLDDCTCDV ETIDRFNNYR
    61  LFPRLQKLLE SDYFRYYKVN LKRPCPFWND ISQCGRRDCA VKPCQSDEVP DGIKSASYKY
   121  SEEANNLIEE CEQAERLGAV DESLSEETQK AVLQWTKHDD SSDNFCEADD IQSPEAEYVD
   181  LLLNPERYTG YKGPDAWKIW NVIYEENCFK PQTIKRPLNP LASGQGTSEE NTFYSWLEGL
   241  CVEKRAFYRL ISGLHASINV HLSARYLLQE TWLEKKWGHN ITEFQQRFDG ILTEGEGPRR
   301  LKNLYFLYLI ELRALSKVLP FFERPDFQLF TGNKIQDEEN KMLLLEILHE IKSFPLHFDE
   361  NSFFAGDKKE AHKLKEDFRL HFRNISRIMD CVGCFKCRLW GKLQTQGLGT ALKILFSEKL
   421  IANMPESGPS YEFHLTRQEI VSLFNAFGRI STSVKELENF RNLLQNIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERO1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
169 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 169 nTPM
  • cervix: 67 nTPM
  • vagina: 65 nTPM
  • bone marrow: 44 nTPM
  • placenta: 42 nTPM
  • salivary gland: 35 nTPM

Single-cell type

  • esophageal apical cells: 10,958 nCPM
  • pancreatic acinar cells: 544 nCPM
  • extravillous trophoblasts: 318 nCPM
  • urothelial cells: 305 nCPM
  • neutrophil progenitors: 295 nCPM
  • pancreatic duct cells: 249 nCPM

Immune cell

  • basophil: 21 nTPM
  • neutrophil: 15 nTPM
  • T-reg: 12 nTPM
  • eosinophil: 12 nTPM
  • MAIT T-cell: 11 nTPM
  • non-classical monocyte: 9.5 nTPM

Brain region

  • hypothalamus: 33 nTPM
  • midbrain: 27 nTPM
  • thalamus: 26 nTPM
  • pons: 26 nTPM
  • cerebral cortex: 25 nTPM
  • basal ganglia: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.81
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERO1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERO1A as an antibody target. Whether an autoantibody or antibody against ERO1A could matter depends on whether native ERO1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERO1A is annotated as secreted, so native ERO1A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ERO1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERO1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...