OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
Also known as: OST4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0C6T2
- Gene
- OST4
- Ensembl
- ENSG00000228474
- Chromosome
- 2
- Canonical length
- 37 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex A and oligosaccharyltransferase complex B. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
37 residues, UniProt reviewed canonical sequence.
>P0C6T2|OST4
1 MITDVQLAIF ANMLGVSLFL LVVLYHYVAV NNPKKQELocalizationUniProt · AlphaFold · HPA
Whether an antibody against OST4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 608 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 608 nTPM
- choroid plexus: 536 nTPM
- ovary: 510 nTPM
- tongue: 498 nTPM
- blood vessel: 489 nTPM
- kidney: 473 nTPM
Single-cell type
- platelets: 5,798 nCPM
- megakaryocytes: 3,196 nCPM
- esophageal apical cells: 1,569 nCPM
- esophageal suprabasal cells: 1,406 nCPM
- decidual stromal cells: 1,159 nCPM
- extravillous trophoblasts: 1,096 nCPM
Immune cell
- total PBMC: 4,748 nTPM
- basophil: 3,195 nTPM
- plasmacytoid DC: 2,623 nTPM
- eosinophil: 2,138 nTPM
- T-reg: 1,825 nTPM
- memory CD4 T-cell: 1,758 nTPM
Brain region
- hypothalamus: 186 nTPM
- white matter: 185 nTPM
- pons: 159 nTPM
- spinal cord: 159 nTPM
- medulla oblongata: 158 nTPM
- midbrain: 156 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.74
- gnomAD pLI
- 0.39
- gnomAD missense Z
- 0.79
- DepMap mean gene effect
- -0.39
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Oligosaccaryltransferase
- Oligosaccharyltransferase subunit ost4p superfamily
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
- Oligosaccaryltransferase
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of OST4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OST4 as an antibody target. Whether an autoantibody or antibody against OST4 could matter depends on whether native OST4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OST4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label OST4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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