Seroatlas · Human Serome Atlas

ORC6

Origin recognition complex subunit 6

Also known as: ORC6_HUMAN, ORC6L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5N6
Gene
ORC6
Ensembl
ENSG00000091651
Chromosome
16
Canonical length
252 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>Q9Y5N6|ORC6
     1  MGSELIGRLA PRLGLAEPDM LRKAEEYLRL SRVKCVGLSA RTTETSSAVM CLDLAASWMK
    61  CPLDRAYLIK LSGLNKETYQ SCLKSFECLL GLNSNIGIRD LAVQFSCIEA VNMASKILKS
   121  YESSLPQTQQ VDLDLSRPLF TSAALLSACK ILKLKVDKNK MVATSGVKKA IFDRLCKQLE
   181  KIGQQVDREP GDVATPPRKR KKIVVEAPAK EMEKVEEMPH KPQKDEDLTQ DYEEWKRKIL
   241  ENAASAQKAT AE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ORC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
9.7 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 9.7 nTPM
  • testis: 9.3 nTPM
  • lymph node: 6.9 nTPM
  • tonsil: 6.8 nTPM
  • thymus: 5.7 nTPM
  • esophagus: 3.9 nTPM

Single-cell type

  • early primary spermatocytes: 154 nCPM
  • differentiating spermatogonia: 91 nCPM
  • erythrocyte progenitors: 87 nCPM
  • megakaryocyte progenitors: 68 nCPM
  • migrating cytotrophoblasts: 53 nCPM
  • cytotrophoblasts: 46 nCPM

Immune cell

  • naive B-cell: 1.4 nTPM
  • T-reg: 1.2 nTPM
  • gdT-cell: 1 nTPM
  • plasmacytoid DC: 1 nTPM
  • NK-cell: 0.9 nTPM
  • naive CD4 T-cell: 0.8 nTPM

Brain region

  • basal ganglia: 2.8 nTPM
  • cerebral cortex: 2.5 nTPM
  • hypothalamus: 2.4 nTPM
  • midbrain: 2.4 nTPM
  • white matter: 2.4 nTPM
  • hippocampal formation: 2.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ORC6.

Disease | AllUniProt

Conditions ORC6 is implicated in, by any mechanism.

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 180 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Meier-Gorlin syndrome 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
gnomAD missense Z
-0.49
DepMap mean gene effect
-1.89
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • ORC6, first cyclin-like domain
  • Origin recognition complex, subunit 6, metazoa/plant
  • ORC6, second cyclin-like domain
  • Origin recognition complex subunit 6 (ORC6)
  • ORC6 second cyclin-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ORC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ORC6 as an antibody target. Whether an autoantibody or antibody against ORC6 could matter depends on whether native ORC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ORC6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ORC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ORC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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