Seroatlas · Human Serome Atlas

OOEP

Oocyte-expressed protein homolog

Also known as: C6orf156, Em:AC019205.2, KHDC2, OOEP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NGQ2
Gene: OOEP
Ensembl: ENSG00000203907
Chromosome: 6
Canonical length: 149 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be involved in several processes, including cytoskeleton organization; positive regulation of double-strand break repair via homologous recombination; and positive regulation of meiotic nuclear division. Predicted to act upstream of or within several processes, including embryo implantation; in utero embryonic development; and protein phosphorylation. Located in cytoplasm and nucleus. Part of subcortical maternal complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

149 residues, UniProt reviewed canonical sequence.

>A6NGQ2|OOEP
     1  MVDDAGAAES QRGKQTPAHS LEQLRRLPLP PPQIRIRPWW FPVQELRDPL VFYLEAWLAD
    61  ELFGPDRAII PEMEWTSQAL LTVDIVDSGN LVEITVFGRP RVQNRVKSML LCLAWFHREH
   121  RARAEKMKHL EKNLKAHASD PHSPQDPVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OOEP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
salivary gland: 1.7 nTPM
placenta: 1.3 nTPM
pancreas: 0.9 nTPM
skin: 0.9 nTPM
blood vessel: 0.5 nTPM

Single-cell type

enteric stem cells: 1,615 nCPM
parietal cells: 1,528 nCPM
gastric chief cells: 1,508 nCPM
enteric transient amplifying cells: 1,262 nCPM
paneth cells: 1,087 nCPM
goblet cells: 973 nCPM

Immune cell

gdT-cell: 0.7 nTPM
memory B-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
T-reg: 0.3 nTPM

Brain region

cerebral cortex: 1.6 nTPM
pons: 0.6 nTPM
white matter: 0.6 nTPM
medulla oblongata: 0.5 nTPM
cerebellum: 0.4 nTPM
hippocampal formation: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OOEP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OOEP as an antibody target. Whether an autoantibody or antibody against OOEP could matter depends on whether native OOEP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OOEP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OOEP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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