Seroatlas · Human Serome Atlas

TLE6

Transducin-like enhancer protein 6

Also known as: FLJ14009, GRG6, TLE6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H808
Gene
TLE6
Ensembl
ENSG00000104953
Chromosome
19
Canonical length
572 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>Q9H808|TLE6
     1  MTSRDQPRPK GPPKSTSPCP GISNSESSPT LNYQGILNRL KQFPRFSPHF AAELESIYYS
    61  LHKIQQDVAE HHKQIGNVLQ IVESCSQLQG FQSEEVSPAE PASPGTPQQV KDKTLQESSF
   121  EDIMATRSSD WLRRPLGEDN QPETQLFWDK EPWFWHDTLT EQLWRIFAGV HDEKAKPRDR
   181  QQAPGLGQES KAPGSCDPGT DPCPEDASTP RPPEASSSPP EGSQDRNTSW GVVQEPPGRA
   241  SRFLQSISWD PEDFEDAWKR PDALPGQSKR LAVPCKLEKM RILAHGELVL ATAISSFTRH
   301  VFTCGRRGIK VWSLTGQVAE DRFPESHLPI QTPGAFLRTC LLSSNSRSLL TGGYNLASVS
   361  VWDLAAPSLH VKEQLPCAGL NCQALDANLD ANLAFASFTS GVVRIWDLRD QSVVRDLKGY
   421  PDGVKSIVVK GYNIWTGGPD ACLRCWDQRT IMKPLEYQFK SQIMSLSHSP QEDWVLLGMA
   481  NGQQWLQSTS GSQRHMVGQK DSVILSVKFS PFGQWWASVG MDDFLGVYSM PAGTKVFEVP
   541  EMSPVTCCDV SSNNRLVVTG SGEHASVYQI TY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLE6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
7.5 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 7.5 nTPM
  • placenta: 4.6 nTPM
  • kidney: 4 nTPM
  • liver: 3.7 nTPM
  • testis: 3.3 nTPM
  • salivary gland: 3.1 nTPM

Single-cell type

  • oocytes: 138 nCPM
  • extravillous trophoblasts: 21 nCPM
  • migrating cytotrophoblasts: 14 nCPM
  • syncytiotrophoblasts: 12 nCPM
  • renal collecting duct principal cells: 12 nCPM
  • differentiating spermatogonia: 11 nCPM

Immune cell

  • NK-cell: 1 nTPM
  • naive B-cell: 0.5 nTPM
  • memory B-cell: 0.4 nTPM
  • T-reg: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • myeloid DC: 0.2 nTPM

Brain region

  • hypothalamus: 5.6 nTPM
  • cerebellum: 3 nTPM
  • midbrain: 1.6 nTPM
  • medulla oblongata: 1.3 nTPM
  • white matter: 1.3 nTPM
  • pons: 1.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TLE6.

Disease | AllUniProt

Conditions TLE6 is implicated in, by any mechanism.

  • Oocyte/zygote/embryo maturation arrest 15 (OZEMA15) MIM:616814

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 167 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Preimplantation embryonic lethality 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TLE6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TLE6 as an antibody target. Whether an autoantibody or antibody against TLE6 could matter depends on whether native TLE6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TLE6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TLE6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TLE6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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