Seroatlas · Human Serome Atlas

BEX1

Protein BEX1

Also known as: BEX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBH7
Gene: BEX1
Ensembl: ENSG00000133169
Chromosome: X
Canonical length: 125 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q9HBH7|BEX1
     1  MESKEKRAVN SLSMENANQE NEEKEQVANK GEPLALPLDA GEYCVPRGNR RRFRVRQPIL
    61  QYRWDMMHRL GEPQARMREE NMERIGEEVR QLMEKLREKQ LSHSLRAVST DPPHHDHHDE
   121  FCLMP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 603 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 603 nTPM
cerebral cortex: 537 nTPM
amygdala: 471 nTPM
basal ganglia: 461 nTPM
pituitary gland: 418 nTPM
hippocampal formation: 370 nTPM

Single-cell type

granulosa cells: 733 nCPM
pancreatic islet cells: 533 nCPM
müller glia: 446 nCPM
sertoli cells: 259 nCPM
other brain neurons: 257 nCPM
retinal horizontal cells: 240 nCPM

Immune cell

eosinophil: 3.4 nTPM
naive CD4 T-cell: 1.4 nTPM
naive B-cell: 1 nTPM
memory CD4 T-cell: 0.9 nTPM
NK-cell: 0.9 nTPM
total PBMC: 0.7 nTPM

Brain region

hypothalamus: 644 nTPM
cerebral cortex: 305 nTPM
pons: 268 nTPM
basal ganglia: 256 nTPM
midbrain: 239 nTPM
hippocampal formation: 205 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0.54
gnomAD missense Z: 0.37
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BEX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEX1 as an antibody target. Whether an autoantibody or antibody against BEX1 could matter depends on whether native BEX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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