OLIG2

Protein identityUniProt · HPA

UniProt accession

Q13516

Gene

OLIG2

Ensembl

ENSG00000205927

Chromosome

21

Canonical length

323 aa

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q13516|OLIG2
     1  MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE LSAELRGAMG
    61  SAGAHPGDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ MTEPELQQLR LKINSRERKR
   121  MHDLNIAMDG LREVMPYAHG PSVRKLSKIA TLLLARNYIL MLTNSLEEMK RLVSEIYGGH
   181  HAGFHPSACG GLAHSAPLPA ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS
   241  ASLPGSGLPS VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV
   301  PPPHHHVSAM GAGSLPRLTS DAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OLIG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.65

Highest tissue expression

58 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0.09

gnomAD missense Z

1.66

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• axon development
• myelination
• negative regulation of neuron differentiation
• negative regulation of transcription by RNA polymerase II
• neuron fate commitment
• positive regulation of oligodendrocyte differentiation
• positive regulation of transcription by RNA polymerase II
• sensory organ development
• spinal cord motor neuron differentiation
• spinal cord oligodendrocyte cell fate specification
• thalamus development

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• E-box binding
• HMG box domain binding
• identical protein binding
• protein dimerization activity
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Myc-type, basic helix-loop-helix (bHLH) domain
• Helix-loop-helix DNA-binding domain superfamily
• Basic helix-loop-helix transcription factors
• Helix-loop-helix DNA-binding domain
• Oligodendrocyte transcription factor 2, basic helix-loop-helix domain

KeywordsUniProt

• Chromosomal rearrangement
• Cytoplasm
• Developmental protein
• DNA-binding
• Nucleus
• Proto-oncogene
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of OLIG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NKX2-2
• ZNF488