Seroatlas · Human Serome Atlas

ZNF488

Zinc finger protein 488

Also known as: FLJ32104, ZN488_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MN9
Gene
ZNF488
Ensembl
ENSG00000265763
Chromosome
10
Canonical length
340 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in oligodendrocyte development and regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of oligodendrocyte differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q96MN9|ZNF488
     1  MPEWPPCLSV APALVITMAA GKGAPLSPSA ENRWRLSEPE LGRGCKPVLL EKTNRLGPEA
    61  AVGRAGRDVG SAELALLVAP GKPRPGKPLP PKTRGEQRQS AFTELPRMKD RQVDAQAQER
   121  EHDDPTGQPG APQLTQNIPR GPAGSKVFSV WPSGARSEQR SAFSKPTKRP AERPELTSVF
   181  PAGESADALG ELSGLLNTTD LACWGRLSTP KLLVGDLWNL QALPQNAPLC STFLGAPTLW
   241  LEHTQAQVPP PSSSSTTSWA LLPPTLTSLG LSTQNWCAKC NLSFRLTSDL VFHMRSHHKK
   301  EHAGPDPHSQ KRREEALACP VCQEHFRERH HLSRHMTSHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF488 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 61 nTPM
  • midbrain: 24 nTPM
  • hippocampal formation: 22 nTPM
  • duodenum: 21 nTPM
  • basal ganglia: 11 nTPM
  • small intestine: 11 nTPM

Single-cell type

  • syncytiotrophoblasts: 43 nCPM
  • oligodendrocytes: 41 nCPM
  • enterocytes: 26 nCPM
  • oligodendrocyte progenitor cells: 14 nCPM
  • retinal amacrine cells: 13 nCPM
  • corticotrophs: 10 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 65 nTPM
  • medulla oblongata: 57 nTPM
  • midbrain: 51 nTPM
  • pons: 50 nTPM
  • cerebellum: 45 nTPM
  • thalamus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
-0.14
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF488 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF488 as an antibody target. Whether an autoantibody or antibody against ZNF488 could matter depends on whether native ZNF488 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF488 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF488 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF488. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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