Seroatlas · Human Serome Atlas

ODAD4

Outer dynein arm-docking complex subunit 4

Also known as: DKFZP434H0115, ODAD4_HUMAN, TTC25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NG3
Gene: ODAD4
Ensembl: ENSG00000204815
Chromosome: 17
Canonical length: 672 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Centrosome,Basal body,Acrosome,Mid piece,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a tetratricopeptide repeat domain-containing protein that localizes to ciliary axonmenes and plays a role in the docking of the outer dynein arm to cilia. Mutations in this gene cause severely reduced ciliary motility and the disorder CILD35 (ciliary dyskinesia,primary, 35). Primary ciliary dyskinesia is often associated with recurrent respiratory infections, immotile spermatozoa, and situs inversus; an inversion in left-right body symmetry. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

672 residues, UniProt reviewed canonical sequence.

>Q96NG3|ODAD4
     1  MSDPEGETLR STFPSYMAEG ERLYLCGEFS KAAQSFSNAL YLQDGDKNCL VARSKCFLKM
    61  GDLERSLKDA EASLQSDPAF CKGILQKAET LYTMGDFEFA LVFYHRGYKL RPDREFRVGI
   121  QKAQEAINNS VGSPSSIKLE NKGDLSFLSK QAENIKAQQK PQPMKHLLHP TKGEPKWKAS
   181  LKSEKTVRQL LGELYVDKEY LEKLLLDEDL IKGTMKGGLT VEDLIMTGIN YLDTHSNFWR
   241  QQKPIYARER DRKLMQEKWL RDHKRRPSQT AHYILKSLED IDMLLTSGSA EGSLQKAEKV
   301  LKKVLEWNKE EVPNKDELVG NLYSCIGNAQ IELGQMEAAL QSHRKDLEIA KEYDLPDAKS
   361  RALDNIGRVF ARVGKFQQAI DTWEEKIPLA KTTLEKTWLF HEIGRCYLEL DQAWQAQNYG
   421  EKSQQCAEEE GDIEWQLNAS VLVAQAQVKL RDFESAVNNF EKALERAKLV HNNEAQQAII
   481  SALDDANKGI IRELRKTNYV ENLKEKSEGE ASLYEDRIIT REKDMRRVRD EPEKVVKQWD
   541  HSEDEKETDE DDEAFGEALQ SPASGKQSVE AGKARSDLGA VAKGLSGELG TRSGETGRKL
   601  LEAGRRESRE IYRRPSGELE QRLSGEFSRQ EPEELKKLSE VGRREPEELG KTQFGEIGET
   661  KKTGNEMEKE YE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ODAD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

testis: 23 nTPM
fallopian tube: 16 nTPM
choroid plexus: 12 nTPM
hypothalamus: 3.4 nTPM
pituitary gland: 3.3 nTPM
basal ganglia: 2.6 nTPM

Single-cell type

late primary spermatocytes: 308 nCPM
respiratory ciliated cells: 269 nCPM
early spermatids: 215 nCPM
fallopian tube ciliated cells: 195 nCPM
ependymal cells: 110 nCPM
epididymal efferent duct ciliated cells: 109 nCPM

Immune cell

plasmacytoid DC: 0.3 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 13 nTPM
midbrain: 5.8 nTPM
medulla oblongata: 5.7 nTPM
hypothalamus: 4.2 nTPM
spinal cord: 3.5 nTPM
pons: 2.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ODAD4.

Disease | AllUniProt

Conditions ODAD4 is implicated in, by any mechanism.

Ciliary dyskinesia, primary, 35 (CILD35) MIM:617092

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 94 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Primary ciliary dyskinesia 35
ODAD4-related disorder
Heterotaxy
Primary ciliary dyskinesia
Colorectal cancer

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat
Outer dynein arm-docking complex subunit 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ODAD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ODAD4 as an antibody target. Whether an autoantibody or antibody against ODAD4 could matter depends on whether native ODAD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ODAD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ODAD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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