Seroatlas · Human Serome Atlas

OCIAD2

OCIA domain-containing protein 2

Also known as: MGC45416, OCAD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q56VL3
Gene: OCIAD2
Ensembl: ENSG00000145247
Chromosome: 4
Canonical length: 154 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in endocytosis; hematopoietic stem cell homeostasis; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within response to bacterium. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q56VL3|OCIAD2
     1  MASASARGNQ DKDAHFPPPS KQSLLFCPKS KLHIHRAEIS KIMRECQEES FWKRALPFSL
    61  VSMLVTQGLV YQGYLAANSR FGSLPKVALA GLLGFGLGKV SYIGVCQSKF HFFEDQLRGA
   121  GFGPQHNRHC LLTCEECKIK HGLSEKGDSQ PSAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OCIAD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 145 nTPM

Expression across tissuesHPA

Tissue

kidney: 145 nTPM
liver: 121 nTPM
duodenum: 115 nTPM
small intestine: 83 nTPM
stomach: 80 nTPM
colon: 51 nTPM

Single-cell type

enterocytes: 634 nCPM
epididymal efferent duct absorptive cells: 617 nCPM
gastric progenitor cells: 483 nCPM
colonocytes: 326 nCPM
gastric chief cells: 315 nCPM
parietal cells: 299 nCPM

Immune cell

T-reg: 340 nTPM
naive CD4 T-cell: 248 nTPM
basophil: 209 nTPM
memory CD4 T-cell: 192 nTPM
memory B-cell: 169 nTPM
naive CD8 T-cell: 166 nTPM

Brain region

hippocampal formation: 23 nTPM
hypothalamus: 19 nTPM
choroid plexus: 15 nTPM
amygdala: 15 nTPM
cerebral cortex: 15 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OCIAD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OCIAD2 as an antibody target. Whether an autoantibody or antibody against OCIAD2 could matter depends on whether native OCIAD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OCIAD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OCIAD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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