Seroatlas · Human Serome Atlas

O00370

LINE-1 retrotransposable element ORF2 protein

Also known as: LORF2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00370
Gene: O00370
Canonical length: 1275 aa

OverviewNCBI Gene

No narrative summary is available for O00370 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1275 residues, UniProt reviewed canonical sequence.

>O00370|O00370
     1  MTGSNSHITI LTLNVNGLNS PIKRHRLASW IKSQDPSVCC IQETHLTCRD THRLKIKGWR
    61  KIYQANGKQK KAGVAILVSD KTDFKPTKIK RDKEGHYIMV KGSIQQEELT ILNIYAPNTG
   121  APRFIKQVLS DLQRDLDSHT LIMGDFNTPL SILDRSTRQK VNKDTQELNS ALHQTDLIDI
   181  YRTLHPKSTE YTFFSAPHHT YSKIDHIVGS KALLSKCKRT EIITNYLSDH SAIKLELRIK
   241  NLTQSRSTTW KLNNLLLNDY WVHNEMKAEI KMFFETNENK DTTYQNLWDA FKAVCRGKFI
   301  ALNAYKRKQE RSKIDTLTSQ LKELEKQEQT HSKASRRQEI TKIRAELKEI ETQKTLQKIN
   361  ESRSWFFERI NKIDRPLARL IKKKREKNQI DTIKNDKGDI TTDPTEIQTT IREYYKHLYA
   421  NKLENLEEMD TFLDTYTLPR LNQEEVESLN RPITGSEIVA IINSLPTKKS PGPDGFTAEF
   481  YQRYKEELVP FLLKLFQSIE KEGILPNSFY EASIILIPKP GRDTTKKENF RPISLMNIDA
   541  KILNKILANR IQQHIKKLIH HDQVGFIPGM QGWFNIRKSI NVIQHINRAK DKNHVIISID
   601  AEKAFDKIQQ PFMLKTLNKL GIDGMYLKII RAIYDKPTAN IILNGQKLEA FPLKTGTRQG
   661  CPLSPLLFNI VLEVLARAIR QEKEIKGIQL GKEEVKLSLF ADDMIVYLEN PIVSAQNLLK
   721  LISNFSKVSG YKINVQKSQA FLYNNNRQTE SQIMGELPFT IASKRIKYLG IQLTRDVKDL
   781  FKENYKPLLK EIKEDTNKWK NIPCSWVGRI NIVKMAILPK VIYRFNAIPI KLPMTFFTEL
   841  EKTTLKFIWN QKRARIAKSI LSQKNKAGGI TLPDFKLYYK ATVTKTAWYW YQNRDIDQWN
   901  RTEPSEIMPH IYNYLIFDKP EKNKQWGKDS LLNKWCWENW LAICRKLKLD PFLTPYTKIN
   961  SRWIKDLNVK PKTIKTLEEN LGITIQDIGV GKDFMSKTPK AMATKDKIDK WDLIKLKSFC
  1021  TAKETTIRVN RQPTTWEKIF ATYSSDKGLI SRIYNELKQI YKKKTNNPIK KWAKDMNRHF
  1081  SKEDIYAAKK HMKKCSSSLA IREMQIKTTM RYHLTPVRMA IIKKSGNNRC WRGCGEIGTL
  1141  VHCWWDCKLV QPLWKSVWRF LRDLELEIPF DPAIPLLGIY PKDYKSCCYK DTCTRMFIAA
  1201  LFTIAKTWNQ PNCPTMIDWI KKMWHIYTME YYAAIKNDEF ISFVGTWMKL ETIILSKLSQ
  1261  EQKTKHRIFS LIGGN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against O00370 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24

OntologyGO

Biological processes

Molecular functions

metal ion binding
RNA binding
RNA-directed DNA polymerase activity
type II site-specific deoxyribonuclease activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads O00370 as an antibody target. Whether an autoantibody or antibody against O00370 could matter depends on whether native O00370 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

O00370 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label O00370 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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