NUDT5

Protein identityUniProt · HPA

UniProt accession

Q9UKK9

Gene

NUDT5

Ensembl

ENSG00000165609

Chromosome

10

Canonical length

219 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Centrosome,Mid piece

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q9UKK9|NUDT5
     1  MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD
    61  GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK
   121  GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ
   181  RLDALVAEEH LTVDARVYSY ALALKHANAK PFEVPFLKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDT5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.35

Highest tissue expression

83 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.88

gnomAD pLI

0

gnomAD missense Z

0.52

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ATP generation from poly-ADP-D-ribose
• chromatin remodeling
• D-ribose catabolic process
• nucleobase-containing small molecule metabolic process
• nucleoside phosphate metabolic process
• nucleotide metabolic process
• ribonucleoside diphosphate catabolic process
• ribose phosphate metabolic process

Molecular functions

• 8-oxo-dGDP phosphatase activity
• ADP-ribose diphosphatase activity
• ADP-sugar diphosphatase activity
• identical protein binding
• magnesium ion binding
• nucleotidyltransferase activity
• protein homodimerization activity
• snoRNA binding

Cellular components

• cytosol
• extracellular exosome
• nucleus

Protein domainsUniProt · Pfam · InterPro

• NUDIX hydrolase domain
• NUDIX hydrolase-like domain superfamily
• NUDIX hydrolase, conserved site
• NUDIX hydrolase
• NUDIX domain

KeywordsUniProt

• Acetylation
• Hydrolase
• Isopeptide bond
• Magnesium
• Metal-binding
• Nucleus
• Phosphoprotein
• RNA-binding
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of NUDT5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PARG
• PPAT