Seroatlas · Human Serome Atlas

PARG

Poly(ADP-ribose) glycohydrolase

Also known as: PARG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86W56
Gene: PARG
Ensembl: ENSG00000227345
Chromosome: 10
Canonical length: 976 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

976 residues, UniProt reviewed canonical sequence.

>Q86W56|PARG
     1  MNAGPGCEPC TKRPRWGAAT TSPAASDARS FPSRQRRVLD PKDAHVQFRV PPSSPACVPG
    61  RAGQHRGSAT SLVFKQKTIT SWMDTKGIKT AESESLDSKE NNNTRIESMM SSVQKDNFYQ
   121  HNVEKLENVS QLSLDKSPTE KSTQYLNQHQ TAAMCKWQNE GKHTEQLLES EPQTVTLVPE
   181  QFSNANIDRS PQNDDHSDTD SEENRDNQQF LTTVKLANAK QTTEDEQARE AKSHQKCSKS
   241  CDPGEDCASC QQDEIDVVPE SPLSDVGSED VGTGPKNDNK LTRQESCLGN SPPFEKESEP
   301  ESPMDVDNSK NSCQDSEADE ETSPGFDEQE DGSSSQTANK PSRFQARDAD IEFRKRYSTK
   361  GGEVRLHFQF EGGESRTGMN DLNAKLPGNI SSLNVECRNS KQHGKKDSKI TDHFMRLPKA
   421  EDRRKEQWET KHQRTERKIP KYVPPHLSPD KKWLGTPIEE MRRMPRCGIR LPLLRPSANH
   481  TVTIRVDLLR AGEVPKPFPT HYKDLWDNKH VKMPCSEQNL YPVEDENGER TAGSRWELIQ
   541  TALLNKFTRP QNLKDAILKY NVAYSKKWDF TALIDFWDKV LEEAEAQHLY QSILPDMVKI
   601  ALCLPNICTQ PIPLLKQKMN HSITMSQEQI ASLLANAFFC TFPRRNAKMK SEYSSYPDIN
   661  FNRLFEGRSS RKPEKLKTLF CYFRRVTEKK PTGLVTFTRQ SLEDFPEWER CEKPLTRLHV
   721  TYEGTIEENG QGMLQVDFAN RFVGGGVTSA GLVQEEIRFL INPELIISRL FTEVLDHNEC
   781  LIITGTEQYS EYTGYAETYR WSRSHEDGSE RDDWQRRCTE IVAIDALHFR RYLDQFVPEK
   841  MRRELNKAYC GFLRPGVSSE NLSAVATGNW GCGAFGGDAR LKALIQILAA AAAERDVVYF
   901  TFGDSELMRD IYSMHIFLTE RKLTVGDVYK LLLRYYNEEC RNCSTPGPDI KLYPFIYHAV
   961  ESCAETADHS GQRTGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

kidney: 12 nTPM
skeletal muscle: 11 nTPM
lymph node: 8.5 nTPM
thymus: 8.5 nTPM
tonsil: 8.5 nTPM
parathyroid gland: 8.4 nTPM

Single-cell type

cardiomyocytes: 417 nCPM
epicardial cells: 364 nCPM
myonuclei: 188 nCPM
adipocytes: 158 nCPM
proximal tubule cells: 138 nCPM
distal convoluted tubule cells: 133 nCPM

Immune cell

basophil: 6.1 nTPM
NK-cell: 3.9 nTPM
naive CD4 T-cell: 3.7 nTPM
naive CD8 T-cell: 3.5 nTPM
non-classical monocyte: 3.5 nTPM
MAIT T-cell: 3.2 nTPM

Brain region

cerebellum: 21 nTPM
cerebral cortex: 14 nTPM
hypothalamus: 14 nTPM
white matter: 14 nTPM
pons: 14 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.39
gnomAD missense Z: 2.11

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

poly(ADP-ribose) glycohydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Poly(ADP-ribose) glycohydrolase
Poly (ADP-ribose) glycohydrolase (PARG), catalytic domain
Poly (ADP-ribose) glycohydrolase, helical domain
Poly (ADP-ribose) glycohydrolase (PARG), Macro domain fold
Poly (ADP-ribose) glycohydrolase (PARG), helical domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARG as an antibody target. Whether an autoantibody or antibody against PARG could matter depends on whether native PARG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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