Seroatlas · Human Serome Atlas

NTS

Neurotensin/neuromedin N

Also known as: NEUT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30990
Gene
NTS
Ensembl
ENSG00000133636
Chromosome
12
Canonical length
170 aa
Protein class
Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to digestive system

OverviewNCBI Gene

This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>P30990|NTS
     1  MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH VPSWKMTLLN
    61  VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA MLTIYQLHKI CHSRAFQHWE
   121  LIQEDILDTG NDKNGKEEVI KRKIPYILKR QLYENKPRRP YILKRDSYYY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NTS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
156 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 156 nTPM
  • hypothalamus: 35 nTPM
  • stomach: 35 nTPM
  • pituitary gland: 31 nTPM
  • hippocampal formation: 15 nTPM
  • midbrain: 13 nTPM

Single-cell type

  • neuroendocrine cells: 6,928 nCPM
  • lymphatic endothelial cells: 590 nCPM
  • respiratory secretory cells: 388 nCPM
  • respiratory deuterosomal cells: 219 nCPM
  • enterocytes: 204 nCPM
  • conjunctival goblet cells: 167 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 59 nTPM
  • hypothalamus: 44 nTPM
  • medulla oblongata: 27 nTPM
  • midbrain: 21 nTPM
  • cerebral cortex: 20 nTPM
  • white matter: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
gnomAD missense Z
-0.23
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Neurotensin/neuromedin N
  • Neurotensin/neuromedin N precursor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NTS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NTS as an antibody target. Whether an autoantibody or antibody against NTS could matter depends on whether native NTS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NTS is annotated as secreted, so native NTS circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label NTS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NTS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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