NTSR1
Neurotensin receptor type 1
Also known as: NTR, NTR1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P30989
- Gene
- NTSR1
- Ensembl
- ENSG00000101188
- Chromosome
- 20
- Canonical length
- 418 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins, Transporters
- Subcellular location
- Plasma membrane
OverviewNCBI Gene
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
418 residues, UniProt reviewed canonical sequence.
>P30989|NTSR1
1 MRLNSSAPGT PGTPAADPFQ RAQAGLEEAL LAPGFGNASG NASERVLAAP SSELDVNTDI
61 YSKVLVTAVY LALFVVGTVG NTVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLTLLLAM
121 PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM
181 SRSRTKKFIS AIWLASALLA VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVVIQVN
241 TFMSFIFPMV VISVLNTIIA NKLTVMVRQA AEQGQVCTVG GEHSTFSMAI EPGRVQALRH
301 GVRVLRAVVI AFVVCWLPYH VRRLMFCYIS DEQWTPFLYD FYHYFYMVTN ALFYVSSTIN
361 PILYNLVSAN FRHIFLATLA CLCPVWRRRR KRPAFSRKAD SVSSNHTLSS NATRETLYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NTSR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 9.8 nTPM
Expression across tissuesHPA
Tissue
- colon: 9.8 nTPM
- midbrain: 1.4 nTPM
- small intestine: 0.9 nTPM
- bone marrow: 0.5 nTPM
- cerebral cortex: 0.4 nTPM
- hypothalamus: 0.4 nTPM
Single-cell type
- neutrophils: 33 nCPM
- retinal bipolar cells: 18 nCPM
- monocytes: 15 nCPM
- müller glia: 8.6 nCPM
- rod photoreceptor cells: 7.7 nCPM
- epicardial cells: 6.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 25 nTPM
- cerebral cortex: 4.4 nTPM
- basal ganglia: 3.8 nTPM
- hippocampal formation: 3.6 nTPM
- thalamus: 2.9 nTPM
- amygdala: 2.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.37
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.42
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adult locomotory behavior
- cAMP biosynthetic process
- chemical synaptic transmission
- conditioned place preference
- D-aspartate import across plasma membrane
- detection of temperature stimulus involved in sensory perception of pain
- G protein-coupled receptor signaling pathway
- L-glutamate import across plasma membrane
- negative regulation of apoptotic process
- negative regulation of release of sequestered calcium ion into cytosol
- negative regulation of systemic arterial blood pressure
- neuropeptide signaling pathway
- positive regulation of apoptotic process
- positive regulation of arachidonate secretion
- positive regulation of gamma-aminobutyric acid secretion
- positive regulation of gene expression
- positive regulation of glutamate secretion
- positive regulation of inhibitory postsynaptic potential
- positive regulation of inositol phosphate biosynthetic process
- positive regulation of locomotion
- positive regulation of release of sequestered calcium ion into cytosol
- regulation of behavioral fear response
- regulation of membrane depolarization
- regulation of respiratory gaseous exchange
- response to food
- response to lipid
- response to stress
- temperature homeostasis
- vocalization behavior
- inositol phosphate catabolic process
- regulation of inositol trisphosphate biosynthetic process
Molecular functions
- G protein-coupled neurotensin receptor activity
- G protein-coupled receptor activity
- identical protein binding
- protein-containing complex binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NTSR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NTSR1 as an antibody target. Whether an autoantibody or antibody against NTSR1 could matter depends on whether native NTSR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NTSR1 is annotated at the cell surface, where native NTSR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label NTSR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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