Seroatlas · Human Serome Atlas

NRDC

Nardilysin

Also known as: hNRD1, hNRD2, NRD1, NRDC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43847
Gene
NRDC
Ensembl
ENSG00000078618
Chromosome
1
Canonical length
1151 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

1151 residues, UniProt reviewed canonical sequence.

>O43847|NRDC
     1  MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM PGRNKAKSTC
    61  SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD PEIVKSPSDP KQYRYIKLQN
   121  GLQALLISDL SNMEGKTGNT TDDEEEEEVE EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD
   181  EHDDDLDTED NELEELEERA EARKKTTEKQ SAAALCVGVG SFADPDDLPG LAHFLEHMVF
   241  MGSLKYPDEN GFDAFLKKHG GSDNASTDCE RTVFQFDVQR KYFKEALDRW AQFFIHPLMI
   301  RDAIDREVEA VDSEYQLARP SDANRKEMLF GSLARPGHPM GKFFWGNAET LKHEPRKNNI
   361  DTHARLREFW MRYYSSHYMT LVVQSKETLD TLEKWVTEIF SQIPNNGLPR PNFGHLTDPF
   421  DTPAFNKLYR VVPIRKIHAL TITWALPPQQ QHYRVKPLHY ISWLVGHEGK GSILSFLRKK
   481  CWALALFGGN GETGFEQNST YSVFSISITL TDEGYEHFYE VAYTVFQYLK MLQKLGPEKR
   541  IFEEIRKIED NEFHYQEQTD PVEYVENMCE NMQLYPLQDI LTGDQLLFEY KPEVIGEALN
   601  QLVPQKANLV LLSGANEGKC DLKEKWFGTQ YSIEDIENSW AELWNSNFEL NPDLHLPAEN
   661  KYIATDFTLK AFDCPETEYP VKIVNTPQGC LWYKKDNKFK IPKAYIRFHL ISPLIQKSAA
   721  NVVLFDIFVN ILTHNLAEPA YEADVAQLEY KLVAGEHGLI IRVKGFNHKL PLLFQLIIDY
   781  LAEFNSTPAV FTMITEQLKK TYFNILIKPE TLAKDVRLLI LEYARWSMID KYQALMDGLS
   841  LESLLSFVKE FKSQLFVEGL VQGNVTSTES MDFLKYVVDK LNFKPLEQEM PVQFQVVELP
   901  SGHHLCKVKA LNKGDANSEV TVYYQSGTRS LREYTLMELL VMHMEEPCFD FLRTKQTLGY
   961  HVYPTCRNTS GILGFSVTVG TQATKYNSEV VDKKIEEFLS SFEEKIENLT EEAFNTQVTA
  1021  LIKLKECEDT HLGEEVDRNW NEVVTQQYLF DRLAHEIEAL KSFSKSDLVN WFKAHRGPGS
  1081  KMLSVHVVGY GKYELEEDGT PSSEDSNSSC EVMQLTYLPT SPLLADCIIP ITDIRAFTTT
  1141  LNLLPYHKIV K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRDC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
266 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 266 nTPM
  • tongue: 170 nTPM
  • testis: 89 nTPM
  • heart muscle: 58 nTPM
  • parathyroid gland: 57 nTPM
  • skin: 54 nTPM

Single-cell type

  • late spermatids: 2,895 nCPM
  • neutrophils: 1,166 nCPM
  • early spermatids: 757 nCPM
  • corticotrophs: 610 nCPM
  • myonuclei: 384 nCPM
  • renal collecting duct intercalated cells: 376 nCPM

Immune cell

  • neutrophil: 68 nTPM
  • eosinophil: 50 nTPM
  • basophil: 45 nTPM
  • intermediate monocyte: 35 nTPM
  • classical monocyte: 34 nTPM
  • myeloid DC: 34 nTPM

Brain region

  • pons: 60 nTPM
  • choroid plexus: 58 nTPM
  • thalamus: 58 nTPM
  • white matter: 58 nTPM
  • cerebral cortex: 55 nTPM
  • hypothalamus: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.04
DepMap mean gene effect
-0.4
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRDC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRDC as an antibody target. Whether an autoantibody or antibody against NRDC could matter depends on whether native NRDC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRDC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRDC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NRDC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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