NPR3

Protein identityUniProt · HPA

UniProt accession

P17342

Gene

NPR3

Ensembl

ENSG00000113389

Chromosome

5

Canonical length

541 aa

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>P17342|NPR3
     1  MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP QKIEVLVLLP
    61  QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ VAYEDSDCGN RALFSLVDRV
   121  AAARGAKPDL ILGPVCEYAA APVARLASHW DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA
   181  YAKMGEMMLA LFRHHHWSRA ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK
   241  DLDLEDIVRN IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG
   301  SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM EDYVNMFVEG
   361  FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI AGQVSIDANG DRYGDFSVIA
   421  MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY PWGPLKLRID ENRIVEHTNS SPCKSSGGLE
   481  ESAVTGIVVG ALLGAGLLMA FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV
   541  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NPR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

101 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NPR3.

Disease | AllUniProt

Conditions NPR3 is implicated in, by any mechanism.

• Boudin-Mortier syndrome (BOMOS) MIM:619543

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 268 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Boudin-Mortier syndrome

Disease | ImmuneIEDB

Conditions an epitope on NPR3 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.82

gnomAD pLI

0

gnomAD missense Z

0.81

DepMap mean gene effect

0.16

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• blood vessel remodeling
• negative regulation of cold-induced thermogenesis
• osteoclast proliferation
• positive regulation of relaxation of smooth muscle
• positive regulation of urine volume
• regulation of blood pressure
• regulation of osteoblast proliferation
• response to ischemia
• signal transduction
• skeletal system development

Molecular functions

• chloride ion binding
• G protein-coupled peptide receptor activity
• hormone binding
• natriuretic peptide receptor activity
• peptide binding
• peptide hormone binding
• protein homodimerization activity
• receptor decoy activity

Cellular components

• extracellular exosome
• plasma membrane
• protein-containing complex

Protein domainsUniProt · Pfam · InterPro

• Adenylyl cyclase class-4/guanylyl cyclase
• Receptor, ligand binding region
• Periplasmic binding protein-like I
• Receptor family ligand binding region
• Atrial Natriuretic Peptide Clearance Receptor

KeywordsUniProt

• Cell membrane
• Chloride
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of NPR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• OSTN