OSTN
Osteocrin
Also known as: OSTN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P61366
- Gene
- OSTN
- Ensembl
- ENSG00000188729
- Chromosome
- 3
- Canonical length
- 133 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
Predicted to enable signaling receptor binding activity. Involved in negative regulation of dendrite extension. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
133 residues, UniProt reviewed canonical sequence.
>P61366|OSTN
1 MLDWRLASAH FILAVTLTLW SSGKVLSVDV TTTEAFDSGV IDVQSTPTVR EEKSATDLTA
61 KLLLLDELVS LENDVIETKK KRSFSGFGSP LDRLSAGSVD HKGKQRKVVD HPKRRFGIPM
121 DRIGRNRLSN SRGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OSTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 1.2 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 1.2 nTPM
- cervix: 1 nTPM
- tongue: 0.5 nTPM
- urinary bladder: 0.5 nTPM
- prostate: 0.4 nTPM
- skin: 0.4 nTPM
Single-cell type
- bergmann glia: 19 nCPM
- b-cells: 11 nCPM
- thymic myoid cells: 11 nCPM
- late primary spermatocytes: 8.9 nCPM
- early spermatids: 7.5 nCPM
- adipocytes: 7.4 nCPM
Immune cell
- memory B-cell: 0.4 nTPM
- naive B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebral cortex: 0.9 nTPM
- basal ganglia: 0.7 nTPM
- hypothalamus: 0.6 nTPM
- medulla oblongata: 0.5 nTPM
- amygdala: 0.4 nTPM
- spinal cord: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.75
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.15
- DepMap mean gene effect
- 0.19
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- bone growth
- cell differentiation
- cell surface receptor signaling pathway
- endochondral bone growth
- hormone-mediated signaling pathway
- negative regulation of D-glucose import
- negative regulation of dendrite extension
- negative regulation of osteoblast differentiation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Osteocrin
- Insulin-resistance promoting peptide in skeletal muscle
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of OSTN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OSTN as an antibody target. Whether an autoantibody or antibody against OSTN could matter depends on whether native OSTN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OSTN is annotated as secreted, so native OSTN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label OSTN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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