Seroatlas · Human Serome Atlas

NOL12

Nucleolar protein 12

Also known as: MGC3731, NOL12_HUMAN, Nop25, RRP17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGY1
Gene: NOL12
Ensembl: ENSG00000273899
Chromosome: 22
Canonical length: 213 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitotic chromosome,Vesicles

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q9UGY1|NOL12
     1  MGRNKKKKRD GDDRRPRLVL SFDEEKRREY LTGFHKRKVE RKKAAIEEIK QRLKEEQRKL
    61  REERHQEYLK MLAEREEALE EADELDRLVT AKTESVQYDH PNHTVTVTTI SDLDLSGARL
   121  LGLTPPEGGA GDRSEEEASS TEKPTKALPR KSRDPLLSQR ISSLTASLHA HSRKKVKRKH
   181  PRRAQDSKKP PRAPRTSKAQ RRRLTGKARH SGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOL12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

esophagus: 33 nTPM
cerebellum: 32 nTPM
adrenal gland: 28 nTPM
bone marrow: 27 nTPM
spleen: 25 nTPM
spinal cord: 24 nTPM

Single-cell type

early spermatids: 50 nCPM
late primary spermatocytes: 36 nCPM
colonocytes: 17 nCPM
enterocytes: 16 nCPM
brain excitatory neurons: 15 nCPM
late spermatids: 15 nCPM

Immune cell

basophil: 57 nTPM
neutrophil: 54 nTPM
non-classical monocyte: 34 nTPM
intermediate monocyte: 29 nTPM
eosinophil: 27 nTPM
classical monocyte: 25 nTPM

Brain region

white matter: 17 nTPM
basal ganglia: 17 nTPM
medulla oblongata: 16 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 16 nTPM
cerebellum: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 0.26
DepMap mean gene effect: -0.71
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleolar protein 12
Nucleolar protein 12 (25kDa)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOL12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOL12 as an antibody target. Whether an autoantibody or antibody against NOL12 could matter depends on whether native NOL12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOL12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOL12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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