Seroatlas · Human Serome Atlas

KIAA1191

Putative monooxygenase p33MONOX

Also known as: FLJ21022, p33MONOX, P33MX_HUMAN, p60MONOX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A73
Gene: KIAA1191
Ensembl: ENSG00000122203
Chromosome: 5
Canonical length: 305 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable oxidoreductase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q96A73|KIAA1191
     1  MASRQPEVPA LEASAPLGKM SLPIGIYRRA VSYDDTLEDP APMTPPPSDM GSVPWKPVIP
    61  ERKYQHLAKV EEGEASLPSP AMTLSSAIDS VDKVPVVKAK ATHVIMNSLI TKQTQESIQH
   121  FERQAGLRDA GYTPHKGLTT EETKYLRVAE ALHKLKLQSG EVTKEERQPA SAQSTPSTTP
   181  HSSPKQRPRG WFTSGSSTAL PGPNPSTMDS GSGDKDRNLS DKWSLFGPRS LQKYDSGSFA
   241  TQAYRGAQKP SPLELIRAQA NRMAEDPAAL KPPKMDIPVM EGKKQPPRAH NLKPRDLNVL
   301  TPTGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1191 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 186 nTPM

Expression across tissuesHPA

Tissue

kidney: 186 nTPM
parathyroid gland: 82 nTPM
heart muscle: 81 nTPM
ovary: 81 nTPM
choroid plexus: 71 nTPM
salivary gland: 68 nTPM

Single-cell type

parietal cells: 325 nCPM
esophageal apical cells: 153 nCPM
platelets: 130 nCPM
proximal tubule cells: 88 nCPM
esophageal suprabasal cells: 70 nCPM
pancreatic acinar cells: 66 nCPM

Immune cell

T-reg: 40 nTPM
basophil: 34 nTPM
eosinophil: 33 nTPM
MAIT T-cell: 32 nTPM
naive CD8 T-cell: 30 nTPM
non-classical monocyte: 29 nTPM

Brain region

hypothalamus: 102 nTPM
pons: 99 nTPM
choroid plexus: 96 nTPM
cerebral cortex: 96 nTPM
thalamus: 95 nTPM
basal ganglia: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

oxidoreductase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Putative monooxygenase p33MONOX
P33 mono-oxygenase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIAA1191 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1191 as an antibody target. Whether an autoantibody or antibody against KIAA1191 could matter depends on whether native KIAA1191 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1191 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA1191 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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