Seroatlas · Human Serome Atlas

NLGN4Y

Neuroligin-4, Y-linked

Also known as: KIAA0951, NLGNY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFZ3
Gene: NLGN4Y
Ensembl: ENSG00000165246
Chromosome: Y
Canonical length: 816 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a type I membrane protein that belongs to the family of neuroligins, which are cell adhesion molecules present at the postsynaptic side of the synapse, and may be essential for the formation of functional synapses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

816 residues, UniProt reviewed canonical sequence.

>Q8NFZ3|NLGN4Y
     1  MLRPQGLLWL PLLFTSVCVM LNSNVLLWIT ALAIKFTLID SQAQYPVVNT NYGKIQGLRT
    61  PLPSEILGPV EQYLGVPYAS PPTGERRFQP PESPSSWTGI RNATQFSAVC PQHLDERFLL
   121  HDMLPIWFTT SLDTLMTYVQ DQNEDCLYLN IYVPMEDDIH EQNSKKPVMV YIHGGSYMEG
   181  TGNMIDGSIL ASYGNVIVIT INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA
   241  FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL
   301  ADKVGCNMLD TTDMVECLKN KNYKELIQQT ITPATYHIAF GPVIDGDVIP DDPQILMEQG
   361  EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS NFVDNLYGYP EGKDTLRETI
   421  KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM
   481  KPSWADSAHG DEVPYVFGIP MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV
   541  PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL
   601  NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS KDPHKTGPED
   661  TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK DKRRHETHRH PSPQRNTTND
   721  ITHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY TLTLRRSPDD IPFMTPNTIT
   781  MIPNTLMGMQ PLHTFKTFSG GQNSTNLPHG HSTTRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NLGN4Y can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

seminal vesicle: 6.9 nTPM
prostate: 5.7 nTPM
cerebral cortex: 3.9 nTPM
urinary bladder: 3.1 nTPM
basal ganglia: 2.5 nTPM
hypothalamus: 2.3 nTPM

Single-cell type

oligodendrocyte progenitor cells: 1,238 nCPM
bergmann glia: 437 nCPM
brain inhibitory neurons: 420 nCPM
brain excitatory neurons: 387 nCPM
oligodendrocytes: 282 nCPM
choroid plexus epithelial cells: 270 nCPM

Immune cell

memory B-cell: 0.6 nTPM
memory CD4 T-cell: 0.3 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

white matter: 9.5 nTPM
hippocampal formation: 9.2 nTPM
cerebellum: 8.5 nTPM
cerebral cortex: 8.5 nTPM
hypothalamus: 8.2 nTPM
basal ganglia: 8.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NLGN4Y.

Disease | ImmuneIEDB

Conditions an epitope on NLGN4Y was assayed in.

glioblastoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0.1
gnomAD missense Z: 1.42
DepMap mean gene effect: 0.34
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NLGN4Y in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NRXN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NLGN4Y as an antibody target. Whether an autoantibody or antibody against NLGN4Y could matter depends on whether native NLGN4Y is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NLGN4Y is annotated at the cell surface, where native NLGN4Y is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NLGN4Y as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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