Seroatlas · Human Serome Atlas

NECTIN1

Nectin-1

Also known as: CD111, CLPED1, ED4, HIgR, HVEC, NECT1_HUMAN, Nectin-1, OFC7, PRR, PRR1, PVRL1, PVRR1, SK-12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15223
Gene
NECTIN1
Ensembl
ENSG00000110400
Chromosome
11
Canonical length
517 aa
Protein class
CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted in other tissues
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q15223|NECTIN1
     1  MARMGLAGAA GRWWGLALGL TAFFLPGVHS QVVQVNDSMY GFIGTDVVLH CSFANPLPSV
    61  KITQVTWQKS TNGSKQNVAI YNPSMGVSVL APYRERVEFL RPSFTDGTIR LSRLELEDEG
   121  VYICEFATFP TGNRESQLNL TVMAKPTNWI EGTQAVLRAK KGQDDKVLVA TCTSANGKPP
   181  SVVSWETRLK GEAEYQEIRN PNGTVTVISR YRLVPSREAH QQSLACIVNY HMDRFKESLT
   241  LNVQYEPEVT IEGFDGNWYL QRMDVKLTCK ADANPPATEY HWTTLNGSLP KGVEAQNRTL
   301  FFKGPINYSL AGTYICEATN PIGTRSGQVE VNITEFPYTP SPPEHGRRAG PVPTAIIGGV
   361  AGSILLVLIV VGGIVVALRR RRHTFKGDYS TKKHVYGNGY SKAGIPQHHP PMAQNLQYPD
   421  DSDDEKKAGP LGGSSYEEEE EEEEGGGGGE RKVGGPHPKY DEDAKRPYFT VDEAEARQDG
   481  YGDRTLGYQY DPEQLDLAEN MVSQNDGSFI SKKEWYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NECTIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
127 nTPM

Expression across tissuesHPA

Tissue

  • skin: 127 nTPM
  • esophagus: 121 nTPM
  • vagina: 35 nTPM
  • hippocampal formation: 30 nTPM
  • spinal cord: 28 nTPM
  • cerebral cortex: 27 nTPM

Single-cell type

  • esophageal suprabasal cells: 294 nCPM
  • esophageal apical cells: 261 nCPM
  • urothelial cells: 214 nCPM
  • suprabasal keratinocytes: 208 nCPM
  • prostatic hillock cells: 203 nCPM
  • esophageal basal cells: 181 nCPM

Immune cell

  • plasmacytoid DC: 1.6 nTPM
  • non-classical monocyte: 0.5 nTPM
  • neutrophil: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • white matter: 94 nTPM
  • cerebral cortex: 83 nTPM
  • hippocampal formation: 80 nTPM
  • thalamus: 72 nTPM
  • midbrain: 71 nTPM
  • basal ganglia: 69 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NECTIN1.

Disease | AllUniProt

Conditions NECTIN1 is implicated in, by any mechanism.

  • Ectodermal dysplasia, Margarita Island type (EDMI) MIM:225060
  • Non-syndromic orofacial cleft 7 (OFC7) MIM:225060

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 246 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cleft lip/palate-ectodermal dysplasia syndrome
  • Orofacial cleft 7

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.06
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NECTIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NECTIN1 as an antibody target. Whether an autoantibody or antibody against NECTIN1 could matter depends on whether native NECTIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NECTIN1 is annotated at the cell surface, where native NECTIN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NECTIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NECTIN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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