Seroatlas · Human Serome Atlas

DCPS

m7GpppX diphosphatase

Also known as: DCPS_HUMAN, HINT-5, HINT5, HSL1, HSPC015

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96C86
Gene
DCPS
Ensembl
ENSG00000110063
Chromosome
11
Canonical length
337 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q96C86|DCPS
     1  MADAAPQLGK RKRELDVEEA HAASTEEKEA GVGNGTCAPV RLPFSGFRLQ KVLRESARDK
    61  IIFLHGKVNE ASGDGDGEDA VVILEKTPFQ VEQVAQLLTG SPELQLQFSN DIYSTYHLFP
   121  PRQLNDVKTT VVYPATEKHL QKYLRQDLRL IRETGDDYRN ITLPHLESQS LSIQWVYNIL
   181  DKKAEADRIV FENPDPSDGF VLIPDLKWNQ QQLDDLYLIA ICHRRGIRSL RDLTPEHLPL
   241  LRNILHQGQE AILQRYRMKG DHLRVYLHYL PSYYHLHVHF TALGFEAPGS GVERAHLLAE
   301  VIENLECDPR HYQQRTLTFA LRADDPLLKL LQEAQQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCPS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
80 nTPM

Expression across tissuesHPA

Tissue

  • liver: 80 nTPM
  • kidney: 28 nTPM
  • gallbladder: 15 nTPM
  • choroid plexus: 14 nTPM
  • lymph node: 11 nTPM
  • bone marrow: 10 nTPM

Single-cell type

  • pdcs: 93 nCPM
  • plasma cells: 87 nCPM
  • cholangiocytes: 63 nCPM
  • migrating cytotrophoblasts: 55 nCPM
  • extravillous trophoblasts: 54 nCPM
  • cytotrophoblasts: 51 nCPM

Immune cell

  • plasmacytoid DC: 47 nTPM
  • myeloid DC: 17 nTPM
  • non-classical monocyte: 15 nTPM
  • intermediate monocyte: 15 nTPM
  • T-reg: 15 nTPM
  • memory B-cell: 13 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • cerebellum: 13 nTPM
  • basal ganglia: 10 nTPM
  • cerebral cortex: 10 nTPM
  • hippocampal formation: 10 nTPM
  • hypothalamus: 9.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DCPS.

Disease | AllUniProt

Conditions DCPS is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 120 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Al-Raqad syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
-0.49
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCPS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCPS as an antibody target. Whether an autoantibody or antibody against DCPS could matter depends on whether native DCPS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCPS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCPS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCPS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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