Seroatlas · Human Serome Atlas

NDC1

Nucleoporin NDC1

Also known as: FLJ10407, NDC1_HUMAN, NET3, TMEM48

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTX1
Gene: NDC1
Ensembl: ENSG00000058804
Chromosome: 1
Canonical length: 674 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Nuclear membrane,Plasma membrane,Actin filaments

OverviewNCBI Gene

A structural constituent of nuclear pore. Involved in nuclear pore complex assembly and nuclear pore localization. Located in actin cytoskeleton; nuclear membrane; and plasma membrane. Part of nuclear pore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q9BTX1|NDC1
     1  MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD
    61  SFSDLYSSYV IFYFLLLSVV IIIISIFNVE FYAVVPSIPC SRLALIGKII HPQQLMHSFI
   121  HAAMGMVMAW CAAVITQGQY SFLVVPCTGT NSFGSPAAQT CLNEYHLFFL LTGAFMGYSY
   181  SLLYFVNNMN YLPFPIIQQY KFLRFRRSLL LLVKHSCVES LFLVRNFCIL YYFLGYIPKA
   241  WISTAMNLHI DEQVHRPLDT VSGLLNLSLL YHVWLCGVFL LTTWYVSWIL FKIYATEAHV
   301  FPVQPPFAEG SDECLPKVLN SNPPPIIKYL ALQDLMLLSQ YSPSRRQEVF SLSQPGGHPH
   361  NWTAISRECL NLLNGMTQKL ILYQEAAATN GRVSSSYPVE PKKLNSPEET AFQTPKSSQM
   421  PRPSVPPLVK TSLFSSKLST PDVVSPFGTP FGSSVMNRMA GIFDVNTCYG SPQSPQLIRR
   481  GPRLWTSASD QQMTEFSNPS PSTSISAEGK TMRQPSVIYS WIQNKREQIK NFLSKRVLIM
   541  YFFSKHPEAS IQAVFSDAQM HIWALEGLSH LVAASFTEDR FGVVQTTLPA ILNTLLTLQE
   601  AVDKYFKLPH ASSKPPRISG SLVDTSYKTL RFAFRASLKT AIYRITTTFG EHLNAVQASA
   661  EHQKRLQQFL EFKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

tonsil: 17 nTPM
lymph node: 15 nTPM
rectum: 13 nTPM
thymus: 13 nTPM
colon: 11 nTPM
breast: 10 nTPM

Single-cell type

erythrocyte progenitors: 85 nCPM
monocyte progenitors: 84 nCPM
megakaryocyte progenitors: 53 nCPM
differentiating spermatogonia: 52 nCPM
gastric progenitor cells: 49 nCPM
enteric transient amplifying cells: 43 nCPM

Immune cell

naive CD4 T-cell: 5.3 nTPM
intermediate monocyte: 5 nTPM
MAIT T-cell: 4.7 nTPM
naive CD8 T-cell: 4.1 nTPM
memory B-cell: 3.6 nTPM
T-reg: 3.4 nTPM

Brain region

white matter: 6.9 nTPM
cerebral cortex: 6.5 nTPM
cerebellum: 6.4 nTPM
choroid plexus: 6.4 nTPM
thalamus: 6.4 nTPM
spinal cord: 6.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NDC1.

Disease | AllUniProt

Conditions NDC1 is implicated in, by any mechanism.

Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima (NEDAPA) MIM:621328

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 137 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrima

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 1.09
DepMap mean gene effect: -0.53
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleoporin protein Ndc1-Nup
Nucleoporin protein Ndc1-Nup

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NDC1 as an antibody target. Whether an autoantibody or antibody against NDC1 could matter depends on whether native NDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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