Seroatlas · Human Serome Atlas

NCEH1

Neutral cholesterol ester hydrolase 1

Also known as: AADACL1, KIAA1363, NCEH, NCEH1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PIU2
Gene
NCEH1
Ensembl
ENSG00000144959
Chromosome
3
Canonical length
408 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

Predicted to enable serine hydrolase activity. Predicted to be involved in ether lipid metabolic process. Predicted to act upstream of or within protein dephosphorylation and xenobiotic metabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q6PIU2|NCEH1
     1  MRSSCVLLTA LVALAAYYVY IPLPGSVSDP WKLMLLDATF RGAQQVSNLI HYLGLSHHLL
    61  ALNFIIVSFG KKSAWSSAQV KVTDTDFDGV EVRVFEGPPK PEEPLKRSVV YIHGGGWALA
   121  SAKIRYYDEL CTAMAEELNA VIVSIEYRLV PKVYFPEQIH DVVRATKYFL KPEVLQKYMV
   181  DPGRICISGD SAGGNLAAAL GQQFTQDASL KNKLKLQALI YPVLQALDFN TPSYQQNVNT
   241  PILPRYVMVK YWVDYFKGNY DFVQAMIVNN HTSLDVEEAA AVRARLNWTS LLPASFTKNY
   301  KPVVQTTGNA RIVQELPQLL DARSAPLIAD QAVLQLLPKT YILTCEHDVL RDDGIMYAKR
   361  LESAGVEVTL DHFEDGFHGC MIFTSWPTNF SVGIRTRNSY IKWLDQNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCEH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 20 nTPM
  • kidney: 20 nTPM
  • lung: 19 nTPM
  • retina: 18 nTPM
  • basal ganglia: 16 nTPM
  • adrenal gland: 15 nTPM

Single-cell type

  • pancreatic duct cells: 761 nCPM
  • urothelial cells: 571 nCPM
  • endometrial glandular cells: 367 nCPM
  • alveolar cells type 2: 307 nCPM
  • cardiomyocytes: 274 nCPM
  • endometrial ciliated cells: 265 nCPM

Immune cell

  • classical monocyte: 18 nTPM
  • myeloid DC: 13 nTPM
  • intermediate monocyte: 12 nTPM
  • non-classical monocyte: 7.9 nTPM
  • basophil: 6.9 nTPM
  • total PBMC: 6.4 nTPM

Brain region

  • cerebral cortex: 81 nTPM
  • basal ganglia: 56 nTPM
  • hippocampal formation: 47 nTPM
  • pons: 43 nTPM
  • thalamus: 40 nTPM
  • white matter: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.01
gnomAD missense Z
0.67
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCEH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCEH1 as an antibody target. Whether an autoantibody or antibody against NCEH1 could matter depends on whether native NCEH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCEH1 is annotated at the cell surface, where native NCEH1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NCEH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NCEH1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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