MTCH2

Protein identityUniProt · HPA

UniProt accession

Q9Y6C9

Gene

MTCH2

Ensembl

ENSG00000109919

Chromosome

11

Canonical length

303 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Mitochondria

OverviewNCBI Gene

This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q9Y6C9|MTCH2
     1  MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH
    61  IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV
   121  IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA
   181  GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV
   241  SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK
   301  MLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTCH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

108 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.56

gnomAD pLI

0.03

gnomAD missense Z

1.2

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to radiation
• establishment of protein localization to mitochondrial membrane involved in mitochondrial fission
• hematopoietic stem cell homeostasis
• hematopoietic stem cell migration
• hepatocyte apoptotic process
• lactate metabolic process
• lipid homeostasis
• mitochondrial ATP synthesis coupled electron transport
• negative regulation of glycolytic process
• negative regulation of mitochondrial membrane potential
• positive regulation of apoptotic process
• positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
• positive regulation of stem cell differentiation
• protein insertion into mitochondrial outer membrane
• protein localization to mitochondrion
• regulation of mitochondrial fusion
• regulation of mitochondrial membrane permeability involved in apoptotic process

Molecular functions

• membrane insertase activity

Cellular components

• membrane
• mitochondrial outer membrane
• mitochondrion
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Mitochondrial carrier protein, transmembrane region
• Mitochondrial carrier protein domain superfamily
• Mitochondrial carrier protein

KeywordsUniProt

• Acetylation
• Membrane
• Mitochondrion
• Mitochondrion outer membrane
• Repeat
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of MTCH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BID
• MUL1