Seroatlas · Human Serome Atlas

TMEM186

Transmembrane protein 186

Also known as: C16orf51, DKFZP564K2062, TM186_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96B77
Gene: TMEM186
Ensembl: ENSG00000184857
Chromosome: 16
Canonical length: 213 aa
Protein class: Predicted membrane proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q96B77|TMEM186
     1  MAALLRAVRR FRGKAVWERP LHGLWCCSGQ EDPKRWVGSS SPISKEKLPN AETEKFWMFY
    61  RFDAIRTFGF LSRLKLAQTA LTVVALPPGY YLYSQGLLTL NTVCLMSGIS GFALTMLCWM
   121  SYFLRRLVGI LYLNESGTML RVAHLNFWGW RQDTYCPMAD VIPLTETKDR PQEMFVRIQR
   181  YSGKQTFYVT LRYGRILDRE RFTQVFGVHQ MLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM186 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

tongue: 20 nTPM
skeletal muscle: 18 nTPM
liver: 16 nTPM
choroid plexus: 13 nTPM
heart muscle: 13 nTPM
epididymis: 12 nTPM

Single-cell type

late spermatids: 190 nCPM
late primary spermatocytes: 56 nCPM
early spermatids: 45 nCPM
cytotrophoblasts: 28 nCPM
esophageal basal cells: 25 nCPM
migrating cytotrophoblasts: 23 nCPM

Immune cell

naive CD4 T-cell: 14 nTPM
non-classical monocyte: 13 nTPM
memory B-cell: 13 nTPM
T-reg: 12 nTPM
naive B-cell: 12 nTPM
naive CD8 T-cell: 11 nTPM

Brain region

choroid plexus: 7.1 nTPM
white matter: 6.8 nTPM
basal ganglia: 6.4 nTPM
thalamus: 6.4 nTPM
hypothalamus: 6.3 nTPM
pons: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -1.25
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial respiratory chain complex I assembly

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM186 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MT-ND3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM186 as an antibody target. Whether an autoantibody or antibody against TMEM186 could matter depends on whether native TMEM186 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM186 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM186 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...