Seroatlas · Human Serome Atlas

MMP13

Collagenase 3

Also known as: CLG3, MMP13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P45452
Gene
MMP13
Ensembl
ENSG00000137745
Chromosome
11
Canonical length
471 aa
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>P45452|MMP13
     1  MHPGVLAAFL FLSWTHCRAL PLPSGGDEDD LSEEDLQFAE RYLRSYYHPT NLAGILKENA
    61  ASSMTERLRE MQSFFGLEVT GKLDDNTLDV MKKPRCGVPD VGEYNVFPRT LKWSKMNLTY
   121  RIVNYTPDMT HSEVEKAFKK AFKVWSDVTP LNFTRLHDGI ADIMISFGIK EHGDFYPFDG
   181  PSGLLAHAFP PGPNYGGDAH FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM
   241  FPIYTYTGKS HFMLPDDDVQ GIQSLYGPGD EDPNPKHPKT PDKCDPSLSL DAITSLRGET
   301  MIFKDRFFWR LHPQQVDAEL FLTKSFWPEL PNRIDAAYEH PSHDLIFIFR GRKFWALNGY
   361  DILEGYPKKI SELGLPKEVK KISAAVHFED TGKTLLFSGN QVWRYDDTNH IMDKDYPRLI
   421  EEDFPGIGDK VDAVYEKNGY IYFFNGPIQF EYSIWSNRIV RVMPANSILW C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMP13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 11 nTPM
  • lung: 0.8 nTPM
  • blood vessel: 0.5 nTPM
  • pituitary gland: 0.5 nTPM
  • bone marrow: 0.3 nTPM
  • vagina: 0.3 nTPM

Single-cell type

  • respiratory basal cells: 4.6 nCPM
  • basal prostatic cells: 3.3 nCPM
  • gonadotrophs: 2.3 nCPM
  • respiratory deuterosomal cells: 2.1 nCPM
  • distal convoluted tubule cells: 2 nCPM
  • basal keratinocytes: 1.9 nCPM

Immune cell

  • basophil: 0.6 nTPM
  • neutrophil: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM

Brain region

  • medulla oblongata: 0.9 nTPM
  • hypothalamus: 0.8 nTPM
  • pons: 0.8 nTPM
  • white matter: 0.8 nTPM
  • basal ganglia: 0.7 nTPM
  • midbrain: 0.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MMP13.

Disease | AllUniProt

Conditions MMP13 is implicated in, by any mechanism.

  • Spondyloepimetaphyseal dysplasia, Missouri type (SEMDM) MIM:602111
  • Metaphyseal anadysplasia 1 (MANDP1) MIM:602111
  • Metaphyseal dysplasia, Spahr type (MDST) MIM:250400

Disease | GeneticClinVar

31 pathogenic / likely-pathogenic of 390 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spondyloepimetaphyseal dysplasia, Missouri type
  • Metaphyseal chondrodysplasia, Spahr type
  • Metaphyseal anadysplasia 1, autosomal dominant
  • MMP13-related disorder
  • Lung cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.52
gnomAD pLI
0
gnomAD missense Z
-0.21
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MMP13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMP13 as an antibody target. Whether an autoantibody or antibody against MMP13 could matter depends on whether native MMP13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMP13 is annotated as secreted, so native MMP13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MMP13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MMP13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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