MIEN1
Migration and invasion enhancer 1
Also known as: C17orf37, C35, MGC14832, MIEN1_HUMAN, ORB3, Rdx12, XTP4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BRT3
- Gene
- MIEN1
- Ensembl
- ENSG00000141741
- Chromosome
- 17
- Canonical length
- 115 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in cytoplasmic side of plasma membrane and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>Q9BRT3|MIEN1
1 MSGEPGQTSV APPPEEVEPG SGVRIVVEYC EPCGFEATYL ELASAVKEQY PGIEIESRLG
61 GTGAFEIEIN GQLVFSKLEN GGFPYEKDLI EAIRRASNGE TLEKITNSRP PCVILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MIEN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 51 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 51 nTPM
- kidney: 41 nTPM
- salivary gland: 38 nTPM
- spinal cord: 37 nTPM
- midbrain: 36 nTPM
- heart muscle: 35 nTPM
Single-cell type
- gastric progenitor cells: 464 nCPM
- esophageal apical cells: 444 nCPM
- syncytiotrophoblasts: 342 nCPM
- late primary spermatocytes: 272 nCPM
- esophageal suprabasal cells: 270 nCPM
- epididymal principal cells: 243 nCPM
Immune cell
- basophil: 139 nTPM
- neutrophil: 134 nTPM
- total PBMC: 120 nTPM
- memory B-cell: 110 nTPM
- eosinophil: 108 nTPM
- non-classical monocyte: 105 nTPM
Brain region
- white matter: 29 nTPM
- cerebellum: 29 nTPM
- hypothalamus: 27 nTPM
- thalamus: 27 nTPM
- basal ganglia: 27 nTPM
- midbrain: 26 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.72
- gnomAD pLI
- 0.55
- gnomAD missense Z
- 0.22
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic process
- negative regulation of apoptotic process
- positive regulation of cell migration
- positive regulation of filopodium assembly
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MIEN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MIEN1 as an antibody target. Whether an autoantibody or antibody against MIEN1 could matter depends on whether native MIEN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MIEN1 is annotated at the cell surface, where native MIEN1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MIEN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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