Seroatlas · Human Serome Atlas

MICU1

Calcium uptake protein 1, mitochondrial

Also known as: CALC, CBARA1, EFHA3, FLJ12684, MICU1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BPX6
Gene
MICU1
Ensembl
ENSG00000107745
Chromosome
10
Canonical length
476 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>Q9BPX6|MICU1
     1  MFRLNSLSAL AELAVGSRWY HGGSQPIQIR RRLMMVAFLG ASAVTASTGL LWKRAHAESP
    61  PCVDNLKSDI GDKGKNKDEG DVCNHEKKTA DLAPHPEEKK KKRSGFRDRK VMEYENRIRA
   121  YSTPDKIFRY FATLKVISEP GEAEVFMTPE DFVRSITPNE KQPEHLGLDQ YIIKRFDGKK
   181  ISQEREKFAD EGSIFYTLGE CGLISFSDYI FLTTVLSTPQ RNFEIAFKMF DLNGDGEVDM
   241  EEFEQVQSII RSQTSMGMRH RDRPTTGNTL KSGLCSALTT YFFGADLKGK LTIKNFLEFQ
   301  RKLQHDVLKL EFERHDPVDG RITERQFGGM LLAYSGVQSK KLTAMQRQLK KHFKEGKGLT
   361  FQEVENFFTF LKNINDVDTA LSFYHMAGAS LDKVTMQQVA RTVAKVELSD HVCDVVFALF
   421  DCDGNGELSN KEFVSIMKQR LMRGLEKPKD MGFTRLMQAM WKCAQETAWD FALPKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICU1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
109 nTPM

Expression across tissuesHPA

Tissue

  • liver: 109 nTPM
  • kidney: 98 nTPM
  • cerebellum: 84 nTPM
  • tongue: 72 nTPM
  • skeletal muscle: 70 nTPM
  • adrenal gland: 52 nTPM

Single-cell type

  • myonuclei: 860 nCPM
  • neutrophils: 624 nCPM
  • neutrophil progenitors: 481 nCPM
  • foveolar cells: 419 nCPM
  • brain excitatory neurons: 325 nCPM
  • proximal tubule cells: 286 nCPM

Immune cell

  • eosinophil: 112 nTPM
  • classical monocyte: 60 nTPM
  • non-classical monocyte: 55 nTPM
  • intermediate monocyte: 50 nTPM
  • neutrophil: 50 nTPM
  • total PBMC: 35 nTPM

Brain region

  • cerebellum: 93 nTPM
  • hippocampal formation: 64 nTPM
  • cerebral cortex: 64 nTPM
  • basal ganglia: 59 nTPM
  • pons: 57 nTPM
  • amygdala: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MICU1.

Disease | AllUniProt

Conditions MICU1 is implicated in, by any mechanism.

  • Myopathy with extrapyramidal signs (MPXPS) MIM:615673

Disease | GeneticClinVar

42 pathogenic / likely-pathogenic of 344 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
1.65
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MICU1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICU1 as an antibody target. Whether an autoantibody or antibody against MICU1 could matter depends on whether native MICU1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICU1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MICU1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MICU1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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