Seroatlas · Human Serome Atlas

SLC25A23

Mitochondrial adenyl nucleotide antiporter SLC25A23

Also known as: APC2, FLJ30339, MGC2615, SCMC3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BV35
Gene
SLC25A23
Ensembl
ENSG00000125648
Chromosome
19
Canonical length
468 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables ADP:phosphate antiporter activity and ATP:phosphate antiporter activity. Involved in mitochondrial transmembrane transport; positive regulation of mitochondrial calcium ion concentration; and regulation of cellular hyperosmotic salinity response. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q9BV35|SLC25A23
     1  MRGSPGDAER RQRWGRLFEE LDSNKDGRVD VHELRQGLAR LGGGNPDPGA QQGISSEGDA
    61  DPDGGLDLEE FSRYLQEREQ RLLLMFHSLD RNQDGHIDVS EIQQSFRALG ISISLEQAEK
   121  ILHSMDRDGT MTIDWQEWRD HFLLHSLENV EDVLYFWKHS TVLDIGECLT VPDEFSKQEK
   181  LTGMWWKQLV AGAVAGAVSR TGTAPLDRLK VFMQVHASKT NRLNILGGLR SMVLEGGIRS
   241  LWRGNGINVL KIAPESAIKF MAYEQIKRAI LGQQETLHVQ ERFVAGSLAG ATAQTIIYPM
   301  EVLKTRLTLR RTGQYKGLLD CARRILEREG PRAFYRGYLP NVLGIIPYAG IDLAVYETLK
   361  NWWLQQYSHD SADPGILVLL ACGTISSTCG QIASYPLALV RTRMQAQASI EGGPQLSMLG
   421  LLRHILSQEG MRGLYRGIAP NFMKVIPAVS ISYVVYENMK QALGVTSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC25A23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
364 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 364 nTPM
  • hippocampal formation: 307 nTPM
  • amygdala: 288 nTPM
  • cerebral cortex: 283 nTPM
  • hypothalamus: 106 nTPM
  • midbrain: 101 nTPM

Single-cell type

  • colonocytes: 148 nCPM
  • esophageal apical cells: 144 nCPM
  • enterocytes: 117 nCPM
  • late spermatids: 104 nCPM
  • salivary duct cells: 95 nCPM
  • ocular epithelial cells: 94 nCPM

Immune cell

  • gdT-cell: 2 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • T-reg: 1.3 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • memory B-cell: 1 nTPM

Brain region

  • basal ganglia: 434 nTPM
  • hippocampal formation: 368 nTPM
  • cerebral cortex: 353 nTPM
  • amygdala: 241 nTPM
  • white matter: 174 nTPM
  • pons: 167 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
1.7
DepMap mean gene effect
-0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC25A23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC25A23 as an antibody target. Whether an autoantibody or antibody against SLC25A23 could matter depends on whether native SLC25A23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC25A23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC25A23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC25A23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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