Seroatlas · Human Serome Atlas

MICU2

Calcium uptake protein 2, mitochondrial

Also known as: EFHA1, MICU2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYU8
Gene
MICU2
Ensembl
ENSG00000165487
Chromosome
13
Canonical length
434 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables several functions, including calcium channel regulator activity; calcium ion sensor activity; and protein heterodimerization activity. Involved in calcium import into the mitochondrion; cellular response to calcium ion; and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial intermembrane space. Part of uniplex complex. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q8IYU8|MICU2
     1  MAAAAGSCAR VAAWGGKLRR GLAVSRQAVR SPGPLAAAVA GAALAGAGAA WHHSRVSVAA
    61  RDGSFTVSAQ KNVEHGIIYI GKPSLRKQRF MQFSSLEHEG EYYMTPRDFL FSVMFEQMER
   121  KTSVKKLTKK DIEDTLSGIQ TAGCGSTFFR DLGDKGLISY TEYLFLLTIL TKPHSGFHVA
   181  FKMLDTDGNE MIEKREFFKL QKIISKQDDL MTVKTNETGY QEAIVKEPEI NTTLQMRFFG
   241  KRGQRKLHYK EFRRFMENLQ TEIQEMEFLQ FSKGLSFMRK EDFAEWLLFF TNTENKDIYW
   301  KNVREKLSAG ESISLDEFKS FCHFTTHLED FAIAMQMFSL AHRPVRLAEF KRAVKVATGQ
   361  ELSNNILDTV FKIFDLDGDE CLSHEEFLGV LKNRMHRGLW VPQHQSIQEY WKCVKKESIK
   421  GVKEVWKQAG KGLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICU2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 71 nTPM
  • tongue: 57 nTPM
  • heart muscle: 54 nTPM
  • skeletal muscle: 53 nTPM
  • parathyroid gland: 43 nTPM
  • retina: 42 nTPM

Single-cell type

  • rod photoreceptor cells: 309 nCPM
  • adrenal medulla cells: 287 nCPM
  • retinal horizontal cells: 281 nCPM
  • retinal ganglion cells: 243 nCPM
  • b-cells: 218 nCPM
  • retinal amacrine cells: 214 nCPM

Immune cell

  • memory B-cell: 42 nTPM
  • T-reg: 40 nTPM
  • eosinophil: 35 nTPM
  • basophil: 34 nTPM
  • memory CD8 T-cell: 31 nTPM
  • gdT-cell: 31 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • cerebellum: 32 nTPM
  • white matter: 32 nTPM
  • cerebral cortex: 31 nTPM
  • medulla oblongata: 29 nTPM
  • spinal cord: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.51
gnomAD pLI
0
gnomAD missense Z
-0.31
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MICU2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICU2 as an antibody target. Whether an autoantibody or antibody against MICU2 could matter depends on whether native MICU2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICU2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MICU2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MICU2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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