Seroatlas · Human Serome Atlas

MCUR1

Mitochondrial calcium uniporter regulator 1

Also known as: C6orf79, CCDC90A, FLJ20958, MCUR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96AQ8
Gene
MCUR1
Ensembl
ENSG00000050393
Chromosome
6
Canonical length
359 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Involved in calcium import into the mitochondrion; calcium ion import; and positive regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q96AQ8|MCUR1
     1  MDCGSVGGQR TQRLPGRQRL LFLPVGLSGR PGGSETSARR CLSALSDGLG ALRPRAPAAR
    61  GGVSRASPLL LLLLVPSPRL AAAAPRRQLG DWERSRLGYA APPAGRSSAW RCSPGVAAAA
   121  GALPQYHGPA PALVSCRREL SLSAGSLQLE RKRRDFTSSG SRKLYFDTHA LVCLLEDNGF
   181  ATQQAEIIVS ALVKILEANM DIVYKDMVTK MQQEITFQQV MSQIANVKKD MIILEKSEFS
   241  ALRAENEKIK LELHQLKQQV MDEVIKVRTD TKLDFNLEKS RVKELYSLNE KKLLELRTEI
   301  VALHAQQDRA LTQTDRKIET EVAGLKTMLE SHKLDNIKYL AGSIFTCLTV ALGFYRLWI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCUR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • retina: 76 nTPM
  • kidney: 21 nTPM
  • cerebral cortex: 18 nTPM
  • midbrain: 18 nTPM
  • skeletal muscle: 18 nTPM
  • duodenum: 18 nTPM

Single-cell type

  • esophageal apical cells: 639 nCPM
  • rod photoreceptor cells: 517 nCPM
  • platelets: 317 nCPM
  • breast lactating cells: 239 nCPM
  • megakaryocytes: 192 nCPM
  • enterocytes: 181 nCPM

Immune cell

  • basophil: 4.2 nTPM
  • myeloid DC: 3.2 nTPM
  • total PBMC: 2.9 nTPM
  • memory CD8 T-cell: 2.2 nTPM
  • memory CD4 T-cell: 2.1 nTPM
  • plasmacytoid DC: 2 nTPM

Brain region

  • thalamus: 20 nTPM
  • cerebral cortex: 20 nTPM
  • pons: 19 nTPM
  • hypothalamus: 18 nTPM
  • midbrain: 17 nTPM
  • basal ganglia: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MCUR1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
-0.24
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCUR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCUR1 as an antibody target. Whether an autoantibody or antibody against MCUR1 could matter depends on whether native MCUR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCUR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCUR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCUR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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