Seroatlas · Human Serome Atlas

DENR

Density-regulated protein

Also known as: DENR_HUMAN, DRP, DRP1, SMAP-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43583
Gene
DENR
Ensembl
ENSG00000139726
Chromosome
12
Canonical length
198 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>O43583|DENR
     1  MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN
    61  FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI
   121  PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE
   181  KWPEVDDDSI EDLGEVKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DENR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 56 nTPM
  • parathyroid gland: 55 nTPM
  • tongue: 42 nTPM
  • thymus: 36 nTPM
  • lymph node: 34 nTPM
  • tonsil: 33 nTPM

Single-cell type

  • esophageal apical cells: 215 nCPM
  • early primary spermatocytes: 204 nCPM
  • extravillous trophoblasts: 174 nCPM
  • differentiating spermatogonia: 164 nCPM
  • esophageal suprabasal cells: 141 nCPM
  • megakaryocyte progenitors: 122 nCPM

Immune cell

  • basophil: 229 nTPM
  • non-classical monocyte: 70 nTPM
  • eosinophil: 58 nTPM
  • intermediate monocyte: 53 nTPM
  • T-reg: 49 nTPM
  • naive CD4 T-cell: 49 nTPM

Brain region

  • cerebral cortex: 41 nTPM
  • midbrain: 40 nTPM
  • hypothalamus: 36 nTPM
  • pons: 35 nTPM
  • basal ganglia: 34 nTPM
  • amygdala: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.88
gnomAD missense Z
1.58
DepMap mean gene effect
-0.78
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DENR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DENR as an antibody target. Whether an autoantibody or antibody against DENR could matter depends on whether native DENR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DENR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DENR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DENR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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