MAT2A

Protein identityUniProt · HPA

UniProt accession

P31153

Gene

MAT2A

Ensembl

ENSG00000168906

Chromosome

2

Canonical length

395 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homotetramer

OverviewNCBI Gene

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>P31153|MAT2A
     1  MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA
    61  KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG
   121  VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS
   181  KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT
   241  IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW
   301  VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI
   361  VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAT2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

825 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAT2A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 330 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Familial thoracic aortic aneurysm and aortic dissection

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.16

gnomAD pLI

1

gnomAD missense Z

3.63

DepMap mean gene effect

-1.73

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to leukemia inhibitory factor
• cellular response to methionine
• one-carbon metabolic process
• positive regulation of TORC1 signaling
• protein heterooligomerization
• protein hexamerization
• S-adenosylmethionine biosynthetic process

Molecular functions

• ATP binding
• identical protein binding
• metal ion binding
• methionine adenosyltransferase activity
• small molecule binding

Cellular components

• cytosol
• methionine adenosyltransferase complex

Protein domainsUniProt · Pfam · InterPro

• S-adenosylmethionine synthetase
• S-adenosylmethionine synthetase, N-terminal
• S-adenosylmethionine synthetase, central domain
• S-adenosylmethionine synthetase, C-terminal
• S-adenosylmethionine synthetase, conserved site
• S-adenosylmethionine synthetase superfamily
• S-adenosylmethionine synthetase, N-terminal domain
• S-adenosylmethionine synthetase, central domain
• S-adenosylmethionine synthetase, C-terminal domain

KeywordsUniProt

• Acetylation
• ATP-binding
• Isopeptide bond
• Magnesium
• Metal-binding
• Nucleotide-binding
• One-carbon metabolism
• Phosphoprotein
• Potassium
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of MAT2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAT1A
• MAT2B