Seroatlas · Human Serome Atlas

MAP7

Ensconsin

Also known as: E-MAP-115, MAP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14244
Gene
MAP7
Ensembl
ENSG00000135525
Chromosome
6
Canonical length
749 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Cytosol

OverviewNCBI Gene

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

749 residues, UniProt reviewed canonical sequence.

>Q14244|MAP7
     1  MAELGAGGDG HRGGDGAVRS ETAPDSYKVQ DKKNASSRPA SAISGQNNNH SGNKPDPPPV
    61  LRVDDRQRLA RERREEREKQ LAAREIVWLE REERARQHYE KHLEERKKRL EEQRQKEERR
   121  RAAVEEKRRQ RLEEDKERHE AVVRRTMERS QKPKQKHNRW SWGGSLHGSP SIHSADPDRR
   181  SVSTMNLSKY VDPVISKRLS SSSATLLNSP DRARRLQLSP WESSVVNRLL TPTHSFLARS
   241  KSTAALSGEA ASCSPIIMPY KAAHSRNSMD RPKLFVTPPE GSSRRRIIHG TASYKKERER
   301  ENVLFLTSGT RRAVSPSNPK ARQPARSRLW LPSKSLPHLP GTPRPTSSLP PGSVKAAPAQ
   361  VRPPSPGNIR PVKREVKVEP EKKDPEKEPQ KVANEPSLKG RAPLVKVEEA TVEERTPAEP
   421  EVGPAAPAMA PAPASAPAPA SAPAPAPVPT PAMVSAPSST VNASASVKTS AGTTDPEEAT
   481  RLLAEKRRLA REQREKEERE RREQEELERQ KREELAQRVA EERTTRREEE SRRLEAEQAR
   541  EKEEQLQRQA EERALREREE AERAQRQKEE EARVREEAER VRQEREKHFQ REEQERLERK
   601  KRLEEIMKRT RRTEATDKKT SDQRNGDIAK GALTGGTEVS ALPCTTNAPG NGKPVGSPHV
   661  VTSHQSKVTV ESTPDLEKQP NENGVSVQNE NFEEIINLPI GSKPSRLDVT NSESPEIPLN
   721  PILAFDDEGT LGPLPQVDGV QTQQTAEVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 86 nTPM
  • retina: 54 nTPM
  • midbrain: 49 nTPM
  • hippocampal formation: 43 nTPM
  • kidney: 32 nTPM
  • basal ganglia: 31 nTPM

Single-cell type

  • oligodendrocytes: 1,846 nCPM
  • retinal bipolar cells: 1,033 nCPM
  • sertoli cells: 662 nCPM
  • thyrotrophs: 656 nCPM
  • retinal horizontal cells: 645 nCPM
  • somatotrophs: 618 nCPM

Immune cell

  • neutrophil: 12 nTPM
  • myeloid DC: 5.7 nTPM
  • non-classical monocyte: 3.1 nTPM
  • basophil: 2.8 nTPM
  • classical monocyte: 2.3 nTPM
  • intermediate monocyte: 1.6 nTPM

Brain region

  • white matter: 309 nTPM
  • basal ganglia: 215 nTPM
  • medulla oblongata: 213 nTPM
  • midbrain: 189 nTPM
  • pons: 184 nTPM
  • thalamus: 180 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.42
gnomAD missense Z
0.7
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP7 as an antibody target. Whether an autoantibody or antibody against MAP7 could matter depends on whether native MAP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP7 is annotated at the cell surface, where native MAP7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAP7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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